Omp85, an evolutionarily conserved bacterial protein involved in outer-membrane-protein assembly

• Published in: Research in Microbiology Vol. 155; no. 3; pp. 129 - 135
• Main Authors: Voulhoux, Romé, Tommassen, Jan
• Format: Book Review Journal Article
• Language: English
• Published: Paris Elsevier SAS 01.04.2004; Elsevier
• Subjects: Amino Acid Sequence; Bacterial Outer Membrane Proteins - genetics; Bacterial Outer Membrane Proteins - metabolism; Bacterial Outer Membrane Proteins - physiology; Bacteriology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Genes, Bacterial; Genome, Bacterial; Microbiology; Miscellaneous; Models, Molecular; Molecular Sequence Data; Neisseria meningitidis; Neisseria meningitidis - genetics; Neisseria meningitidis - metabolism; Neisseria meningitidis - physiology; Omp85; Outer membrane proteins; Protein Structure, Tertiary; Protein transport; Sequence Alignment; Neisseria meningitidis; Omp85; Protein transport; Outer membrane proteins; Infection; Membrane protein; Microbiology; Bacteriosis; Bacteria; External membrane
• ISSN: 0923-2508; 1769-7123
• DOI: 10.1016/j.resmic.2003.11.007

The insertion of proteins into membranes generally requires the assistance of membrane proteins. A protein, designated Omp85 in Neisseria meningitidis, was shown to be required for the assembly of bacterial outer-membrane proteins. The protein is essential for the viability of the bacteria and is ubiquitous among Gram-negative bacteria. Omp85 depletion results in the accumulation of aggregates of unfolded outer-membrane proteins, and we argue that Omp85 is directly involved in outer-membrane-protein assembly. Omp85 shows sequence similarity with Toc75 of the chloroplast protein-import machinery, suggesting a common evolutionary origin.