Non-targeted Metabolomics Profiling of Plasma Samples From Patients With Major Depressive Disorder
Major depressive disorder (MDD) is a neuropsychiatric disorder caused by multiple factors. Although there are clear guidelines for the diagnosis of MDD, the direct and objective diagnostic methods remain inadequate thus far. This study aims to discover peripheral biomarkers in patients with MDD and...
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Published in | Frontiers in psychiatry Vol. 12; p. 810302 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
21.02.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Major depressive disorder (MDD) is a neuropsychiatric disorder caused by multiple factors. Although there are clear guidelines for the diagnosis of MDD, the direct and objective diagnostic methods remain inadequate thus far.
This study aims to discover peripheral biomarkers in patients with MDD and promote the diagnosis of MDD. Plasma samples of healthy controls (HCs,
= 52) and patients with MDD (
= 38) were collected, and then, metabolism analysis was performed using ultrahigh-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Heatmap analysis was performed to identify the different metabolites. Meanwhile, receiver operating characteristic (ROC) curves of these differential metabolites were generated.
Six differential metabolites were found by LC-MS/MS analysis. Three of these were increased, including L-aspartic acid (Asp), diethanolamine, and alanine. Three were decreased, including O-acetyl-L-carnitine (LAC), cystine, and fumarate. In addition, LAC, Asp, fumarate, and alanine showed large areas under the curve (AUCs) by ROC analysis.
The study explored differences in peripheral blood between depressed patients and HCs. These results indicated that differential metabolites with large AUCs may have the potential to be promising biomarkers for the diagnosis of MDD. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Mood Disorders, a section of the journal Frontiers in Psychiatry Reviewed by: Tianlu Chen, Shanghai Jiao Tong University, China; Shayne Mason, North-West University, South Africa Edited by: Chuang Wang, Ningbo University, China These authors have contributed equally to this work and share first authorship |
ISSN: | 1664-0640 1664-0640 |
DOI: | 10.3389/fpsyt.2021.810302 |