NIR Photosensitizer for Two-Photon Fluorescent Imaging and Photodynamic Therapy of Tumor

Preparation of near-infrared (NIR) emissive fluorophore for imaging-guided PDT (photodynamic therapy) has attracted enormous attention. Hence, NIR photosensitizers of two-photon (TP) fluorescent imaging and photodynamic therapy are highly desirable. In this contribution, a novel D-π-A structured NIR...

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Published inFrontiers in chemistry Vol. 9; p. 629062
Main Authors Chen, Lujia, Chen, Meijuan, Zhou, Yuping, Ye, Changsheng, Liu, Ruiyuan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 23.02.2021
Subjects
Chemistry
D-π-A structure
imaging-guided photodynamic therapy
NIR emission
NIR photosensiziter
two-photon fluorescent imaging
NIR emission
NIR photosensiziter
imaging-guided photodynamic therapy
two-photon fluorescent imaging
D-π-A structure
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Summary:Preparation of near-infrared (NIR) emissive fluorophore for imaging-guided PDT (photodynamic therapy) has attracted enormous attention. Hence, NIR photosensitizers of two-photon (TP) fluorescent imaging and photodynamic therapy are highly desirable. In this contribution, a novel D-π-A structured NIR photosensitizer (TTRE) is synthesized. TTRE demonstrates near-infrared (NIR) emission, good biocompatibility, and superior photostability, which can act as TP fluorescent agent for clear visualization of cells and vascular in tissue with deep-tissue penetration. The PDT efficacy of TTRE as photosensitizer is exploited and . All these results confirm that TTRE would serve as potential platform for TP fluorescence imaging and imaging-guided photodynamic therapy.
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Reviewed by: Jianhua Zou, Nanjing Tech University, China
Guangle Niu, Shandong University, China
These authors have contributed equally to this work
Edited by: Simone Brogi, Department of Pharmacy, University of Pisa, Italy
Jianjun Du, Dalian University of Technology, China
This article was submitted to Medicinal and Pharmaceutical Chemistry, a section of the journal Frontiers in Chemistry
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.629062