Glycogen Synthase Kinase 3β Modulates the Inflammatory Response Activated by Bacteria, Viruses, and Parasites

Knowledge of glycogen synthase kinase 3β (GSK3β) activity and the molecules identified that regulate its function in infections caused by pathogenic microorganisms is crucial to understanding how the intensity of the inflammatory response can be controlled in the course of infections. In recent year...

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Published inFrontiers in immunology Vol. 12; p. 675751
Main Authors Cortés-Vieyra, Ricarda, Silva-García, Octavio, Gómez-García, Anel, Gutiérrez-Castellanos, Sergio, Álvarez-Aguilar, Cleto, Baizabal-Aguirre, Víctor M
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.05.2021
Subjects
bacteria
glycogen synthase kinase 3β
Immunology
inflammation
inhibitors
parasites
virus
inhibitors
parasites
bacteria
glycogen synthase kinase 3β
inflammation
virus
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Summary:Knowledge of glycogen synthase kinase 3β (GSK3β) activity and the molecules identified that regulate its function in infections caused by pathogenic microorganisms is crucial to understanding how the intensity of the inflammatory response can be controlled in the course of infections. In recent years many reports have described small molecular weight synthetic and natural compounds, proteins, and interference RNA with the potential to regulate the GSK3β activity and reduce the deleterious effects of the inflammatory response. Our goal in this review is to summarize the most recent advances on the role of GSK3β in the inflammatory response caused by bacteria, bacterial virulence factors (i.e. LPS and others), viruses, and parasites and how the regulation of its activity, mainly its inhibition by different type of molecules, modulates the inflammation.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Daniel Fernandes, Federal University of Santa Catarina, Brazil; Kun Yang, East Tennessee State University, United States
Edited by: Christoph Thiemermann, Queen Mary University of London, United Kingdom
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.675751