Stem Cell Paracrine Signaling for Treatment of Premature Ovarian Insufficiency

Premature ovarian insufficiency is a common disorder affecting young women and represents the worst-case ovarian scenario due to the substantial impact on the reproductive lifespan of these patients. Due to the complexity of this condition, which is not fully understood, non-effective treatments hav...

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Published inFrontiers in endocrinology (Lausanne) Vol. 11; p. 626322
Main Authors Polonio, Alba M, García-Velasco, Juan A, Herraiz, Sonia
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.02.2021
Subjects
autologous stem cell ovarian transplant
Endocrinology
follicular rescue
mobilization
ovarian rejuvenation
premature ovarian insufficiency
stem cells
stem cells
autologous stem cell ovarian transplant
follicular rescue
ovarian rejuvenation
mobilization
premature ovarian insufficiency
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Summary:Premature ovarian insufficiency is a common disorder affecting young women and represents the worst-case ovarian scenario due to the substantial impact on the reproductive lifespan of these patients. Due to the complexity of this condition, which is not fully understood, non-effective treatments have yet been established for these patients. Different experimental approaches are being explored and strategies based on stem cells deserve special attention. The regenerative and immunomodulatory properties of stem cells have been successfully tested in different tissues, including ovary. Numerous works point out to the efficacy of stem cells in POI treatment, and a wide range of clinical trials have been developed in order to prove safety and effectiveness of stem cells therapy-in diminished ovarian reserve and POI women. The main purpose of this review is to describe the state of the art of the treatment of POI involving stem cells, especially those that use mobilization of stem cells or paracrine signaling.
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Edited by: Annalisa Racca, University Hospital Brussels, Belgium
This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology
Reviewed by: Sezcan Mumusoglu, Hacettepe University, Turkey; Necati Findikli, Bahçeci Fulya IVF Center, Turkey
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2020.626322