Autophagy in the Regulation of Tissue Differentiation and Homeostasis

Autophagy is a constitutive pathway that allows the lysosomal degradation of damaged components. This conserved process is essential for metabolic plasticity and tissue homeostasis and is crucial for mammalian post-mitotic cells. Autophagy also controls stem cell fate and defective autophagy is invo...

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Published inFrontiers in cell and developmental biology Vol. 8; p. 602901
Main Authors Perrotta, Cristiana, Cattaneo, Maria Grazia, Molteni, Raffaella, De Palma, Clara
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.12.2020
Subjects
autophagy
Cell and Developmental Biology
tissue differentiation
tissue homeostasis
tissue pathophysiology
tissue remodeling
autophagy
tissue pathophysiology
tissue remodeling
tissue differentiation
tissue homeostasis
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Summary:Autophagy is a constitutive pathway that allows the lysosomal degradation of damaged components. This conserved process is essential for metabolic plasticity and tissue homeostasis and is crucial for mammalian post-mitotic cells. Autophagy also controls stem cell fate and defective autophagy is involved in many pathophysiological processes. In this review, we focus on established and recent breakthroughs aimed at elucidating the impact of autophagy in differentiation and homeostasis maintenance of endothelium, muscle, immune system, and brain providing a suitable framework of the emerging results and highlighting the pivotal role of autophagic response in tissue functions, stem cell dynamics and differentiation rates.
Bibliography:ObjectType-Article-2
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Edited by: Federica Di Sano, University of Rome Tor Vergata, Italy
Reviewed by: Zengli Guo, University of North Carolina at Chapel Hill, United States; Chunying Li, Georgia State University, United States
This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2020.602901