Preparation of Electrospun Gelatin Mat with Incorporated Zinc Oxide/Graphene Oxide and Its Antibacterial Activity

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 5; p. 1043
• Main Authors: Li, Honghai, Chen, Yu, Lu, Weipeng, Xu, Yisheng, Guo, Yanchuan, Yang, Geng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 26.02.2020; MDPI AG
• Subjects: Anti-Bacterial Agents - pharmacology; antibacterial activity; electrospinning; Escherichia coli - drug effects; Gelatin - chemical synthesis; Gelatin - chemistry; Gelatin - ultrastructure; gelatin fibers; Graphite - chemistry; Microbial Sensitivity Tests; Nanocomposites - chemistry; Nanocomposites - ultrastructure; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus - drug effects; Thermogravimetry; wound dressing; X-Ray Diffraction; Zinc Oxide - chemistry; zno/go; antibacterial activity; ZnO/GO; wound dressing; electrospinning; gelatin fibers
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25051043

Current wound dressings have poor antimicrobial activities and are difficult to degrade. Therefore, biodegradable and antibacterial dressings are urgently needed. In this article, we used the hydrothermal method and side-by-side electrospinning technology to prepare a gelatin mat with incorporated zinc oxide/graphene oxide (ZnO/GO) nanocomposites. The resultant fibers were characterized by field emission environment scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FTIR). Results indicated that the gelatin fibers had good morphology, and ZnO/GO nanocomposites were uniformly dispersed on the fibers. The loss of ( ) and ( ) viability were observed to more than 90% with the incorporation of ZnO/GO. The degradation process showed that the composite fibers completely degraded within 7 days and had good controllable degradation characteristics. This study demonstrated the potential applicability of ZnO/GO-gelatin mats with excellent antibacterial properties as wound dressing material.