Non-Coding RNAs Regulate Placental Trophoblast Function and Participate in Recurrent Abortion

Recurrent spontaneous abortion (RSA) is a serious pregnancy complication with an increasing clinical incidence. The various causes of recurrent abortion are complicated. Developments in genetics, immunology, and cell biology have identified important roles of non-coding RNAs (ncRNAs) in the occurren...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in pharmacology Vol. 12; p. 646521
Main Authors Chen, Xin, Guo, Duan-Ying, Yin, Tai-Lang, Yang, Jing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 22.04.2021
Subjects
diagnosis
diagnostic biomarker
non-coding RNA
Pharmacology
placental trophoblast
recurrent abortion
recurrent abortion
diagnosis
non-coding RNA
diagnostic biomarker
placental trophoblast
Online AccessGet full text

Cover

More Information
Summary:Recurrent spontaneous abortion (RSA) is a serious pregnancy complication with an increasing clinical incidence. The various causes of recurrent abortion are complicated. Developments in genetics, immunology, and cell biology have identified important roles of non-coding RNAs (ncRNAs) in the occurrence and progress of recurrent abortion. NcRNAs can affect the growth, migration, and invasion of placental trophoblasts by regulating cell processes such as the cell cycle, apoptosis, and epithelial-mesenchymal transformation. Therefore, their abnormal expression might lead to the occurrence and development of RSA. NcRNAs include small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), ribosomal RNA (rRNA), transfer, RNA (tRNA), circular RNA (cRNA), and Piwi-interacting RNA (piRNA). In this review, we discuss recent research that focused on the function and mechanism of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNA (circRNA) in regulating placental trophoblasts. The use of ncRNAs as potential diagnostic and predictive biomarkers in RSA is also discussed to provide future research insights.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
This article was submitted to Obstetric and Pediatric Pharmacology, a section of the journal Frontiers in Pharmacology
Kathleen Job, The University of Utah, United States
Edited by: Guilherme Ramires De Jesús, Rio de Janeiro State University, Brazil
Reviewed by: Laura Avagliano, University of Milan, Italy
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.646521