Epigenetic Regulation in Pathology of Atherosclerosis: A Novel Perspective

Atherosclerosis, characterized by atherosclerotic plaques, is a complex pathological process that involves different cell types and can be seen as a chronic inflammatory disease. In the advanced stage, the ruptured atherosclerotic plaque can induce deadly accidents including ischemic stroke and myoc...

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Published inFrontiers in genetics Vol. 12; p. 810689
Main Authors Tang, Haishuang, Zeng, Zhangwei, Shang, Chenghao, Li, Qiang, Liu, Jianmin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.12.2021
Subjects
atherosclerosis
DNA methylation
epigenetic
Genetics
histone modifications
noncoding RNA modification
atherosclerosis
DNA methylation
noncoding RNA modification
histone modifications
epigenetic
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Summary:Atherosclerosis, characterized by atherosclerotic plaques, is a complex pathological process that involves different cell types and can be seen as a chronic inflammatory disease. In the advanced stage, the ruptured atherosclerotic plaque can induce deadly accidents including ischemic stroke and myocardial infarction. Epigenetics regulation, including DNA methylation, histone modification, and non-coding RNA modification. maintains cellular identity affecting the cellular transcriptome. The epigenetic modification process, mediating by epigenetic enzymes, is dynamic under various stimuli, which can be reversely altered. Recently, numerous studies have evidenced the close relationship between atherosclerosis and epigenetic regulations in atherosclerosis, providing us with a novel perspective in researching mechanisms and finding novel therapeutic targets of this serious disease. Here, we critically review the recent discoveries between epigenetic regulation mechanisms in atherosclerosis.
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Edited by: Yi Li, Cornell University, United States
Reviewed by: Suowen Xu, University of Science and Technology of China, China
This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Genetics
Lasse Folkersen, Danish National Genome Center, Denmark
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2021.810689