The Role of Parietal Epithelial Cells in the Pathogenesis of Podocytopathy

• Published in: Frontiers in physiology Vol. 13; p. 832772
• Main Authors: Li, Zhi-hang, Guo, Xiao-yan, Quan, Xiao-ying, Yang, Chen, Liu, Ze-jian, Su, Hong-yong, An, Ning, Liu, Hua-feng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.03.2022
• Subjects: glomerular; parietal epithelial cells; Physiology; podocyte; podocytopathy; signaling pathway; parietal epithelial cells; podocytopathy; signaling pathway; glomerular; podocyte

Podocytopathy is the most common feature of glomerular disorder characterized by podocyte injury- or dysfunction-induced excessive proteinuria, which ultimately develops into glomerulosclerosis and results in persistent loss of renal function. Due to the lack of self-renewal ability of podocytes, mi...