The Role of Parietal Epithelial Cells in the Pathogenesis of Podocytopathy

Podocytopathy is the most common feature of glomerular disorder characterized by podocyte injury- or dysfunction-induced excessive proteinuria, which ultimately develops into glomerulosclerosis and results in persistent loss of renal function. Due to the lack of self-renewal ability of podocytes, mi...

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Published inFrontiers in physiology Vol. 13; p. 832772
Main Authors Li, Zhi-hang, Guo, Xiao-yan, Quan, Xiao-ying, Yang, Chen, Liu, Ze-jian, Su, Hong-yong, An, Ning, Liu, Hua-feng
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 11.03.2022
Subjects
glomerular
parietal epithelial cells
Physiology
podocyte
podocytopathy
signaling pathway
parietal epithelial cells
podocytopathy
signaling pathway
glomerular
podocyte
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Summary:Podocytopathy is the most common feature of glomerular disorder characterized by podocyte injury- or dysfunction-induced excessive proteinuria, which ultimately develops into glomerulosclerosis and results in persistent loss of renal function. Due to the lack of self-renewal ability of podocytes, mild podocyte depletion triggers replacement and repair processes mostly driven by stem cells or resident parietal epithelial cells (PECs). In contrast, when podocyte recovery fails, activated PECs contribute to the establishment of glomerular lesions. Increasing evidence suggests that PECs, more than just bystanders, have a crucial role in various podocytopathies, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, diabetic nephropathy, IgA nephropathy, and lupus podocytopathy. In this review, we attempt to dissect the diverse role of PECs in the pathogenesis of podocytopathy based on currently available information.
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This article was submitted to Renal and Epithelial Physiology, a section of the journal Frontiers in Physiology
These authors have contributed equally to this work
Edited by: Daria Ilatovskaya, Augusta University, United States
Reviewed by: Denisha R. Spires, Augusta University, United States; Krisztian Stadler, Pennington Biomedical Research Center, United States; Sandeep Mallipattu, Stony Brook University, United States; Justine Abais-Battad, Augusta University, United States
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2022.832772