Red face may be a specific sign of SARS-CoV-2 alpha variant

•Red face was seen in three patients with COVID-19.•Red face may reflect a cytokine storm.•Red face may be predictive of a sudden deterioration. Japan is currently suffering the fourth wave of the COVID-19 pandemic, with the dominant type being SARS-CoV-2 alpha variant. Patients with COVID-19 varian...

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Published inIDCases Vol. 25; p. e01214
Main Authors Nakaya, Aya, Ogura, Eiji, Katayama, Yuki, Yoshii, Masami, Yoshino, Eiko, Hozumi, Kazuya, Tago, Saori, Teranishi, Yuko, Minamibashi, Yuki, Harada, Makiko, Yoshioka, Mami, Kawano, Yuri, Arai, Yuka, Yoshida, Keno, Shimizu, Shozo, Ogura, Kazuma, Iwashita, Katsuaki
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.01.2021
Elsevier
Subjects
Case Report
COVID-19
Cytokine storm
Pneumonia
Red face
SARS-CoV-2 alpha variant
COVID-19
Red face
SARS-CoV-2 alpha variant
Pneumonia
Cytokine storm
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Summary:•Red face was seen in three patients with COVID-19.•Red face may reflect a cytokine storm.•Red face may be predictive of a sudden deterioration. Japan is currently suffering the fourth wave of the COVID-19 pandemic, with the dominant type being SARS-CoV-2 alpha variant. Patients with COVID-19 variant types show more aggressive symptoms. In the present study, three patients developed a red face during treatment. Two of them suddenly worsened shortly after. We assumed that the red face reflected a cytokine storm and conjectured that it may be a specific sign of variant type COVID-19, because we have never seen it in patients with non-variant type. Moreover, we believe that red face may be predictive of a sudden deterioration.
ISSN:2214-2509
2214-2509
DOI:10.1016/j.idcr.2021.e01214