The CXXC-TET bridge - mind the methylation gap

CG-rich DNA ＂reader＂ proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differen- tiation and development. In a recent paper in Nature, Ko et al. show that the CXXC domain protein, IDAX, plays a crucial role as a CG-rich DNA-binding factor in the...

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Bibliographic Details
Published inCell research Vol. 23; no. 8; pp. 973 - 974
Main Authors Dunican, Donncha S, Pennings, Sari, Meehan, Richard R
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.08.2013
Subjects
5-Methylcytosine - metabolism
Animals
Cell differentiation
CpG序列
C结构域
Deoxyribonucleic acid
DNA
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
Humans
Proto-Oncogene Proteins - metabolism
Research Highlight
TET
Transcription Factors - chemistry
Transcription Factors - metabolism
Translocation
差距
甲基化
细胞分化
结合因子
蛋白质结合
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Summary:CG-rich DNA ＂reader＂ proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differen- tiation and development. In a recent paper in Nature, Ko et al. show that the CXXC domain protein, IDAX, plays a crucial role as a CG-rich DNA-binding factor in the regula- tion of Ten-Eleven-Translocation 2 （TET2） protein function.
Bibliography:CG-rich DNA ＂reader＂ proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differen- tiation and development. In a recent paper in Nature, Ko et al. show that the CXXC domain protein, IDAX, plays a crucial role as a CG-rich DNA-binding factor in the regula- tion of Ten-Eleven-Translocation 2 （TET2） protein function.
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ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2013.71