Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage

• Published in: Frontiers in pharmacology Vol. 11; p. 572373
• Main Authors: Xiao, Zhun, Liu, Wei, Mu, Yong-Ping, Zhang, Hua, Wang, Xiao-Ning, Zhao, Chang-Qing, Chen, Jia-Mei, Liu, Ping
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.11.2020
• Subjects: Keap1; Nrf2; oxidative damage; Pharmacology; ROS; salvianolic acid B; Keap1; oxidative damage; salvianolic acid B; Nrf2; ROS
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2020.572373

Salvianolic acid B (Sal B) is one of the main active ingredients of , with strong antioxidant effects. Recent findings have shown that Sal B has anti-inflammatory, anti-apoptotic, anti-fibrotic effects and can promote stem cell proliferation and differentiation, and has a beneficial effect on cardiovascular and cerebrovascular diseases, aging, and liver fibrosis. Reactive oxygen species (ROS) include oxygen free radicals and oxygen-containing non-free radicals. ROS can regulate cell proliferation, survival, death and differentiation to regulate inflammation, and immunity, while Sal B can scavenge oxygen free radicals by providing hydrogen atoms and reduce the production of oxygen free radicals and oxygen-containing non-radicals by regulating the expression of antioxidant enzymes. The many pharmacological effects of Sal B may be closely related to its elimination and inhibition of ROS generation, and Nuclear factor E2-related factor 2/Kelch-like ECH-related protein 1 may be the core link in its regulation of the expression of antioxidant enzyme to exert its antioxidant effect. What is confusing and interesting is that Sal B exhibits the opposite mechanisms in tumors. To clarify the specific target of Sal B and the correlation between its regulation of oxidative stress and energy metabolism homeostasis will help to further understand its role in different pathological conditions, and provide a scientific basis for its further clinical application and new drug development. Although Sal B has broad prospects in clinical application due to its extensive pharmacological effects, the low bioavailability is a serious obstacle to further improving its efficacy and promoting clinical application. Therefore, how to improve the availability of Sal B requires the joint efforts of many interdisciplinary subjects.