Mutations in CCR3 render it missing in action

Allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis have become a serious cause of morbidity in the Western world. [...]there is an ongoing search for molecular and cellular mechanisms that contribute to the pathogenesis of allergic disease.1 Human and animal studies have iden...

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Published inJournal of allergy and clinical immunology Vol. 126; no. 1; pp. 158 - 159
Main Authors Lacy, Paige, PhD, Munitz, Ariel, PhD
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.07.2010
Elsevier Limited
Subjects
Allergy and Immunology
Animals
Asthma
CCR3
Chemokines
Cystic fibrosis
Endoplasmic reticulum
eosinophils
eotaxin
Kinases
Ligands
Mice
Mutation
Polymorphism, Single Nucleotide
Receptors, CCR3 - chemistry
Receptors, CCR3 - genetics
Receptors, CCR3 - physiology
Regulation
Studies
eosinophils
eotaxin
Chemokines
CCR3
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Summary:Allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis have become a serious cause of morbidity in the Western world. [...]there is an ongoing search for molecular and cellular mechanisms that contribute to the pathogenesis of allergic disease.1 Human and animal studies have identified that the accumulation of eosinophils into inflamed tissues is a hallmark of allergic diseases. The degradation of mutant CCR3 molecules is proposed to occur through the endoplasmic reticulum-associated degradation (ERAD) pathway. [...]L324 is likely an important regulatory region of CCR3 maturation and folding, which may interact with chaperones that escort mutant CCR3 molecules to late endosomes and lysosomes for degradation.
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ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.04.027