The effects of Dexmedetomidine on myogenic motor evoked potentials in rabbits

• Published in: Anesthesia and analgesia Vol. 104; no. 6; pp. 1488 - 1492
• Main Authors: YAMAMOTO, Yuri, KAWAGUCHI, Masahiko, KAKIMOTO, Meiko, INOUE, Satoki, FURUYA, Hitoshi
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.06.2007
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Dexmedetomidine - pharmacology; Dose-Response Relationship, Drug; Evoked Potentials, Motor - drug effects; Evoked Potentials, Motor - physiology; Medical sciences; Muscle, Skeletal - drug effects; Muscle, Skeletal - physiology; Rabbits; Reflex - drug effects; Reflex - physiology; α2-Adrenergic receptor; Agonist; Vertebrata; Mammalia; Evoked potential; Animal; Dexmedetomidine; Rabbit; Anesthesia; α-Adrenergic receptor agonist; Lagomorpha
• ISSN: 0003-2999; 1526-7598
• DOI: 10.1213/01.ane.0000261518.62873.91

Dexmedetomidine is used in the perioperative management of patients, including as an intraoperative adjuvant. The effects of dexmedetomidine on myogenic motor evoked potentials (MEPs) remain undetermined. We conducted the present study to investigate the effects of dexmedetomidine on myogenic MEPs in rabbits. New Zealand white rabbits were used for the studies. First, to determine appropriate doses of dexmedetomidine as an adjunct for anesthesia in rabbits, the level of anesthesia was evaluated by testing the palpebral and limb withdrawal reflexes, and the reactions to ear pinching and tail clamp at 5, 25, 50, 100 microg/kg/h. Second, in 10 rabbits under ketamine and fentanyl anesthesia, myogenic MEPs in response to single pulse and a train-of-five pulses were recorded from the soleus muscle before, during, and after the administration of dexmedetomidine at 5, 25, and 50 microg/kg/h. At 50 microg/kg/h of dexmedetomidine, palpebral reflex, limb reflex, and reaction to ear pinching were inhibited in >50% of animals, but the reaction to tail clamp was not reduced. Dexmedetomidine suppressed myogenic MEPs in a dose-dependent manner, but when multipulses were used for stimulation, myogenic MEPs could be recorded in all animals at 50 microg/kg/h. As long as multipulse is used for stimulation, the recording of myogenic MEPs is feasible in rabbits under ketamine and fentanyl anesthesia during the administration of dexmedetomidine at doses that are an adjunct to anesthesia.