Regulator of Chromosome Condensation 2 Modulates Cell Cycle Progression, Tumorigenesis, and Therapeutic Resistance

• Published in: Frontiers in molecular biosciences Vol. 7; p. 620973
• Main Authors: Guo, Kun, Zhao, Cheng, Lang, Bin, Wang, Huiqin, Zheng, Hang, Zhang, Feng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.01.2021
• Subjects: cancer therapeutic resistance; chromosomal passenger complex; DNA damage; Molecular Biosciences; regulator of chromosome condensation 2; tumorgenesis; cancer therapeutic resistance; chromosomal passenger complex; tumorgenesis; DNA damage; regulator of chromosome condensation 2

Accurate regulation of cell cycle is important for normal tissue development and homeostasis. RCC2 (Regulator of Chromosome Condensation 2) play a role as chromosomal passenger complex (CPC) implicated in all cell cycle phases. RCC2 was initially identified as Ran guanine exchange factor (GEF) for s...