Regulator of Chromosome Condensation 2 Modulates Cell Cycle Progression, Tumorigenesis, and Therapeutic Resistance

Accurate regulation of cell cycle is important for normal tissue development and homeostasis. RCC2 (Regulator of Chromosome Condensation 2) play a role as chromosomal passenger complex (CPC) implicated in all cell cycle phases. RCC2 was initially identified as Ran guanine exchange factor (GEF) for s...

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Published inFrontiers in molecular biosciences Vol. 7; p. 620973
Main Authors Guo, Kun, Zhao, Cheng, Lang, Bin, Wang, Huiqin, Zheng, Hang, Zhang, Feng
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.01.2021
Subjects
cancer therapeutic resistance
chromosomal passenger complex
DNA damage
Molecular Biosciences
regulator of chromosome condensation 2
tumorgenesis
cancer therapeutic resistance
chromosomal passenger complex
tumorgenesis
DNA damage
regulator of chromosome condensation 2
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Summary:Accurate regulation of cell cycle is important for normal tissue development and homeostasis. RCC2 (Regulator of Chromosome Condensation 2) play a role as chromosomal passenger complex (CPC) implicated in all cell cycle phases. RCC2 was initially identified as Ran guanine exchange factor (GEF) for small G proteins. Therefore, RCC2 plays a key role in oncogenesis of most cancers. RCC2 is implicated in Colorectal Cancer (CRC), Lung Adenocarcinoma (LUAD), breast cancer, and ovarian cancer. Expression level of RCC2 protein determines regulation of tumor cell proliferation, invasion, metastasis, and radio-chemotherapeutic resistance. In this review, we explored proteins that interact with RCC2 to modulate tumor development and cancer therapeutic resistance by regulation of cell cycle process through various signaling pathways.
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Edited by: Yi Chieh Lim, Danish Cancer Society Research Center (DCRC), Denmark
This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Molecular Biosciences
Reviewed by: Hazel Quek, The University of Queensland, Australia; Diana Aguilar-Morante, Danish Cancer Society, Denmark
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2020.620973