Neurofilaments run sprints not marathons

In neurons, cytoskeletal proteins are transported from where they are made - the cell body - along the axons, but it has long been disputed whether they are transported as subunits or polymers. A new analysis of neurofilament movement may help to resolve the controversy.

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Bibliographic Details
Published inNature cell biology Vol. 2; no. 3; pp. E43 - E45
Main Author Brady, Scott T
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.03.2000
Subjects
Animals
Axonal Transport - physiology
Biological Transport
Cells
Cells, Cultured
Cytoplasmic filaments
Cytoskeleton - metabolism
DNA, Complementary - administration & dosage
Green Fluorescent Proteins
Humans
Luminescent Proteins - genetics
Models, Biological
Motility
Neurites - metabolism
Neurofilament Proteins - genetics
Neurofilament Proteins - metabolism
Neurons - cytology
Neurons - metabolism
Physiological aspects
Polymers
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - metabolism
Space life sciences
Non-programmatic
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Summary:In neurons, cytoskeletal proteins are transported from where they are made - the cell body - along the axons, but it has long been disputed whether they are transported as subunits or polymers. A new analysis of neurofilament movement may help to resolve the controversy.
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ISSN:1465-7392
1476-4679
DOI:10.1038/35004071