Macrophage Related Chronic Inflammation in Non-Healing Wounds

Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage functio...

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Published inFrontiers in immunology Vol. 12; p. 681710
Main Authors Li, Meirong, Hou, Qian, Zhong, Lingzhi, Zhao, Yali, Fu, Xiaobing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.06.2021
Subjects
aging
Animals
Biomarkers
Chronic Disease
chronic inflammation
chronic wound
diabetes
heterogeneity
Humans
Immunology
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
macrophage
Macrophage Activation - genetics
Macrophage Activation - immunology
Macrophages - immunology
Macrophages - metabolism
Regeneration
Wound Healing - immunology
multidimensional analysis
chronic wound
macrophage
aging
diabetes
chronic inflammation
heterogeneity
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Abstract Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage function in healing and non-healing wounds. We consider extrinsic and intrinsic factors driving wound macrophage dysregulation, and review systemic and topical therapeutic approaches for the restoration of macrophage response. Multidimensional analysis is highlighted through the integration of various high-throughput technologies, used to assess the diversity and activation states as well as cellular communication of macrophages in healing and non-healing wound. This research fills the gaps in current literature and provides the promising therapeutic interventions for chronic wounds.
AbstractList Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage function in healing and non-healing wounds. We consider extrinsic and intrinsic factors driving wound macrophage dysregulation, and review systemic and topical therapeutic approaches for the restoration of macrophage response. Multidimensional analysis is highlighted through the integration of various high-throughput technologies, used to assess the diversity and activation states as well as cellular communication of macrophages in healing and non-healing wound. This research fills the gaps in current literature and provides the promising therapeutic interventions for chronic wounds.Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage function in healing and non-healing wounds. We consider extrinsic and intrinsic factors driving wound macrophage dysregulation, and review systemic and topical therapeutic approaches for the restoration of macrophage response. Multidimensional analysis is highlighted through the integration of various high-throughput technologies, used to assess the diversity and activation states as well as cellular communication of macrophages in healing and non-healing wound. This research fills the gaps in current literature and provides the promising therapeutic interventions for chronic wounds.
Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage function in healing and non-healing wounds. We consider extrinsic and intrinsic factors driving wound macrophage dysregulation, and review systemic and topical therapeutic approaches for the restoration of macrophage response. Multidimensional analysis is highlighted through the integration of various high-throughput technologies, used to assess the diversity and activation states as well as cellular communication of macrophages in healing and non-healing wound. This research fills the gaps in current literature and provides the promising therapeutic interventions for chronic wounds.
Author Zhao, Yali
Li, Meirong
Hou, Qian
Zhong, Lingzhi
Fu, Xiaobing
AuthorAffiliation 4 Central Laboratory, Trauma Treatment Center, Central Laboratory, Chinese PLA General Hospital, Hainan Hospital , Sanya , China
3 Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences , Beijing , China
2 PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, PLA General Hospital , Beijing , China
1 Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4 th Medical Center, PLA General Hospital and PLA Medical College , Beijing , China
AuthorAffiliation_xml – name: 4 Central Laboratory, Trauma Treatment Center, Central Laboratory, Chinese PLA General Hospital, Hainan Hospital , Sanya , China
– name: 1 Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4 th Medical Center, PLA General Hospital and PLA Medical College , Beijing , China
– name: 2 PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, PLA General Hospital , Beijing , China
– name: 3 Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences , Beijing , China
Author_xml – sequence: 1
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  surname: Li
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34220830$$D View this record in MEDLINE/PubMed
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Keywords multidimensional analysis
chronic wound
macrophage
aging
diabetes
chronic inflammation
heterogeneity
Language English
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Nandini Ghosh, Vidyasagar University, India; Ramkumar Kunka Mohanram, SRM University, India
Edited by: Giamila Fantuzzi, University of Illinois at Chicago, United States
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fimmu.2021.681710
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  year: 2021
  text: 2021-06-16
  day: 16
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PublicationTitle Frontiers in immunology
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Snippet Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major...
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SubjectTerms aging
Animals
Biomarkers
Chronic Disease
chronic inflammation
chronic wound
diabetes
heterogeneity
Humans
Immunology
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
macrophage
Macrophage Activation - genetics
Macrophage Activation - immunology
Macrophages - immunology
Macrophages - metabolism
Regeneration
Wound Healing - immunology
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Title Macrophage Related Chronic Inflammation in Non-Healing Wounds
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