Macrophage Related Chronic Inflammation in Non-Healing Wounds

Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage functio...

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Published inFrontiers in immunology Vol. 12; p. 681710
Main Authors Li, Meirong, Hou, Qian, Zhong, Lingzhi, Zhao, Yali, Fu, Xiaobing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.06.2021
Subjects
aging
Animals
Biomarkers
Chronic Disease
chronic inflammation
chronic wound
diabetes
heterogeneity
Humans
Immunology
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
macrophage
Macrophage Activation - genetics
Macrophage Activation - immunology
Macrophages - immunology
Macrophages - metabolism
Regeneration
Wound Healing - immunology
multidimensional analysis
chronic wound
macrophage
aging
diabetes
chronic inflammation
heterogeneity
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Summary:Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage function in healing and non-healing wounds. We consider extrinsic and intrinsic factors driving wound macrophage dysregulation, and review systemic and topical therapeutic approaches for the restoration of macrophage response. Multidimensional analysis is highlighted through the integration of various high-throughput technologies, used to assess the diversity and activation states as well as cellular communication of macrophages in healing and non-healing wound. This research fills the gaps in current literature and provides the promising therapeutic interventions for chronic wounds.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Nandini Ghosh, Vidyasagar University, India; Ramkumar Kunka Mohanram, SRM University, India
Edited by: Giamila Fantuzzi, University of Illinois at Chicago, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.681710