Mast Cells in Skin Scarring: A Review of Animal and Human Research

Mast cells (MCs) are an important immune cell type in the skin and play an active role during wound healing. MCs produce mediators that can enhance acute inflammation, stimulate re-epithelialisation as well as angiogenesis, and promote skin scarring. There is also a link between MCs and abnormal pat...

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Bibliographic Details
Published inFrontiers in immunology Vol. 11; p. 552205
Main Authors Ud-Din, Sara, Wilgus, Traci A, Bayat, Ardeshir
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 30.09.2020
Subjects
animal/human research
hypertrophic scars
Immunology
inflammation
keloid scars
mast cell
skin scarring
hypertrophic scars
keloid scars
skin scarring
inflammation
animal/human research
cutaneous wound healing
mast cell
fibrosis
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Summary:Mast cells (MCs) are an important immune cell type in the skin and play an active role during wound healing. MCs produce mediators that can enhance acute inflammation, stimulate re-epithelialisation as well as angiogenesis, and promote skin scarring. There is also a link between MCs and abnormal pathological cutaneous scarring, with increased numbers of MCs found in hypertrophic scars and keloid disease. However, there has been conflicting data regarding the specific role of MCs in scar formation in both animal and human studies. Whilst animal studies have proved to be valuable in studying the MC phenomenon in wound healing, the appropriate translation of these findings to cutaneous wound healing and scar formation in human subjects remains crucial to elucidate the role of these cells and target treatment effectively. Therefore, this perspective paper will focus on evaluation of the current evidence for the role of MCs in skin scarring in both animals and humans in order to identify common themes and future areas for translational research.
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Reviewed by: Yosuke Kurashima, Chiba University, Japan; Aristidis Veves, Beth Israel Deaconess Medical Center and Harvard Medical School, United States
This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Edited by: Stefano Caserta, University of Hull, United Kingdom
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.552205