Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment

• Published in: Nanomedicine (London, England) Vol. 8; no. 3; pp. 727 - 752
• Main Authors: Grillone, Agostina, Battaglini, Matteo, Moscato, Stefania, Mattii, Letizia, de Julián Fernández, César, Scarpellini, Alice, Giorgi, Mario, Sinibaldi, Edoardo, Ciofani, Gianni
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.03.2019
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Apoptosis; Biological Transport; Blood-Brain Barrier; Brain cancer; Cancer therapies; Cell cycle; Cell Line, Tumor; Cell Survival - drug effects; Chemotherapy; Cytotoxicity; Drug Carriers - chemistry; Drug efficacy; Drug Liberation; dynamic fluidic models; Glioblastoma - drug therapy; glioblastoma multiforme; Humans; Imidazoles - chemistry; Imidazoles - therapeutic use; Kinases; Kinetics; Lipids; Lipids - chemistry; Magnetic fields; magnetic targeting; Magnetite Nanoparticles - chemistry; Nanoparticles; nutlin-3a; Particle Size; Physicochemical properties; Piperazines - chemistry; Piperazines - therapeutic use; Proteins; Senescence; solid lipid nanoparticles; Surface Properties; Tumors; glioblastoma multiforme; dynamic fluidic models; blood–brain barrier; magnetic targeting; nutlin-3a; solid lipid nanoparticles

Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Nutlin-3a and superparamagnetic nanoparticles were encap...