Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment

• Published in: Nanomedicine (London, England) Vol. 8; no. 3; pp. 727 - 752
• Main Authors: Grillone, Agostina, Battaglini, Matteo, Moscato, Stefania, Mattii, Letizia, de Julián Fernández, César, Scarpellini, Alice, Giorgi, Mario, Sinibaldi, Edoardo, Ciofani, Gianni
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.03.2019
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Apoptosis; Biological Transport; Blood-Brain Barrier; Brain cancer; Cancer therapies; Cell cycle; Cell Line, Tumor; Cell Survival - drug effects; Chemotherapy; Cytotoxicity; Drug Carriers - chemistry; Drug efficacy; Drug Liberation; dynamic fluidic models; Glioblastoma - drug therapy; glioblastoma multiforme; Humans; Imidazoles - chemistry; Imidazoles - therapeutic use; Kinases; Kinetics; Lipids; Lipids - chemistry; Magnetic fields; magnetic targeting; Magnetite Nanoparticles - chemistry; Nanoparticles; nutlin-3a; Particle Size; Physicochemical properties; Piperazines - chemistry; Piperazines - therapeutic use; Proteins; Senescence; solid lipid nanoparticles; Surface Properties; Tumors; glioblastoma multiforme; dynamic fluidic models; blood–brain barrier; magnetic targeting; nutlin-3a; solid lipid nanoparticles
• ISSN: 1743-5889; 1748-6963; 1748-6963
• DOI: 10.2217/nnm-2018-0436

Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells. Nut-Mag-SLNs showed good colloidal stability, the ability to cross an blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug. Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.