Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment

Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Nutlin-3a and superparamagnetic nanoparticles were encap...

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Published inNanomedicine (London, England) Vol. 8; no. 3; pp. 727 - 752
Main Authors Grillone, Agostina, Battaglini, Matteo, Moscato, Stefania, Mattii, Letizia, de Julián Fernández, César, Scarpellini, Alice, Giorgi, Mario, Sinibaldi, Edoardo, Ciofani, Gianni
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.03.2019
Subjects
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Apoptosis
Biological Transport
Blood-Brain Barrier
Brain cancer
Cancer therapies
Cell cycle
Cell Line, Tumor
Cell Survival - drug effects
Chemotherapy
Cytotoxicity
Drug Carriers - chemistry
Drug efficacy
Drug Liberation
dynamic fluidic models
Glioblastoma - drug therapy
glioblastoma multiforme
Humans
Imidazoles - chemistry
Imidazoles - therapeutic use
Kinases
Kinetics
Lipids
Lipids - chemistry
Magnetic fields
magnetic targeting
Magnetite Nanoparticles - chemistry
Nanoparticles
nutlin-3a
Particle Size
Physicochemical properties
Piperazines - chemistry
Piperazines - therapeutic use
Proteins
Senescence
solid lipid nanoparticles
Surface Properties
Tumors
glioblastoma multiforme
dynamic fluidic models
blood–brain barrier
magnetic targeting
nutlin-3a
solid lipid nanoparticles
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Abstract Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells. Nut-Mag-SLNs showed good colloidal stability, the ability to cross an blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug. Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.
AbstractList Aim: Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Materials & methods: Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells. Results: Nut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood–brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug. Conclusion: Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.
Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells. Nut-Mag-SLNs showed good colloidal stability, the ability to cross an blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug. Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.
Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells. Nut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug. Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.
Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency.AIMGlioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency.Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells.MATERIALS & METHODSNutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells.Nut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug.RESULTSNut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug.Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.CONCLUSIONNut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.
Author Ciofani, Gianni
Battaglini, Matteo
Giorgi, Mario
Moscato, Stefania
de Julián Fernández, César
Scarpellini, Alice
Sinibaldi, Edoardo
Grillone, Agostina
Mattii, Letizia
AuthorAffiliation 2The Biorobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy
1Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinado Piaggio 34, 56025 Pontedera, Italy
7Center for Micro-BioRobotics, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy
5Electron Microscopy Facility, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
6Veterinary Clinics Department, Università di Pisa, Via Livornese 1, 56010 San Piero a Grado, Italy
4Institute of Materials for Electronics & Magnetism, Consiglio Nazionale delle Ricerche-CNR, Parco area delle Scienza 37/A, 43124 Parma, Italy
3Department of Clinical & Experimental Medicine, Università di Pisa, Via Savi 10, 56126 Pisa, Italy
8Department of Mechanical & Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
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– name: 2 The Biorobotics Institute, Scuola Superiore Sant’Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy
– name: 5 Electron Microscopy Facility, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
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  fullname: Ciofani, Gianni
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30574827$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords glioblastoma multiforme
dynamic fluidic models
blood–brain barrier
magnetic targeting
nutlin-3a
solid lipid nanoparticles
Language English
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Snippet Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a...
Aim: Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a...
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SubjectTerms Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Apoptosis
Biological Transport
Blood-Brain Barrier
Brain cancer
Cancer therapies
Cell cycle
Cell Line, Tumor
Cell Survival - drug effects
Chemotherapy
Cytotoxicity
Drug Carriers - chemistry
Drug efficacy
Drug Liberation
dynamic fluidic models
Glioblastoma - drug therapy
glioblastoma multiforme
Humans
Imidazoles - chemistry
Imidazoles - therapeutic use
Kinases
Kinetics
Lipids
Lipids - chemistry
Magnetic fields
magnetic targeting
Magnetite Nanoparticles - chemistry
Nanoparticles
nutlin-3a
Particle Size
Physicochemical properties
Piperazines - chemistry
Piperazines - therapeutic use
Proteins
Senescence
solid lipid nanoparticles
Surface Properties
Tumors
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Title Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment
URI http://dx.doi.org/10.2217/nnm-2018-0436
https://www.ncbi.nlm.nih.gov/pubmed/30574827
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