The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases

Oral microbial dysbiosis is the major causative factor for common oral infectious diseases including dental caries and periodontal diseases. Interventions that can lessen the microbial virulence and reconstitute microbial ecology have drawn increasing attention in the development of novel therapeuti...

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Published inFrontiers in cellular and infection microbiology Vol. 12; p. 816386
Main Authors Yang, Sirui, Lyu, Xiaoying, Zhang, Jin, Shui, Yusen, Yang, Ran, Xu, Xin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.02.2022
Subjects
antimicrobial agents
Cellular and Infection Microbiology
Communicable Diseases
dental caries
Dental Caries - prevention & control
dental plaque biofilm
Dysbiosis
Humans
Microbiota
oral microbiota
periodontal diseases
small molecules
Virulence
dental caries
periodontal diseases
antimicrobial agents
oral microbiota
small molecules
dental plaque biofilm
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Summary:Oral microbial dysbiosis is the major causative factor for common oral infectious diseases including dental caries and periodontal diseases. Interventions that can lessen the microbial virulence and reconstitute microbial ecology have drawn increasing attention in the development of novel therapeutics for oral diseases. Antimicrobial small molecules are a series of natural or synthetic bioactive compounds that have shown inhibitory effect on oral microbiota associated with oral infectious diseases. Novel small molecules, which can either selectively inhibit keystone microbes that drive dysbiosis of oral microbiota or inhibit the key virulence of the microbial community without necessarily killing the microbes, are promising for the ecological management of oral diseases. Here we discussed the research progress in the development of antimicrobial small molecules and delivery systems, with a particular focus on their antimicrobial activity against typical species associated with oral infectious diseases and the underlying mechanisms.
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Edited by: Prasanna Neelakantan, The University of Hong Kong, Hong Kong SAR, China
These authors have contributed equally to this work
This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology
Reviewed by: Hua Xie, Meharry Medical College, United States; Armelia Sari Widyarman, Trisakti University, Indonesia; Xuan Li, The University of Hong Kong, Hong Kong SAR, China
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.816386