Synthesis, characterization and in vitro antimicrobial activity of some 1-(substitutedbenzylidene)-4-(4-(2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl)semicarbazide derivatives

A series of 1-(substitutedbenzylidene)-4-(4-(2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl) phenyl)semicarbazide derivatives were synthesized with the aim of developing potential antimicrobials. It was characterized by FT-IR, 1H NMR, Mass spectroscopy and elemental analysis. In addition, the in vitro a...

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Bibliographic Details
Published inJournal of Saudi Chemical Society Vol. 19; no. 1; pp. 3 - 11
Main Authors Saravanan, Govindaraj, Alagarsamy, Veerachamy, Prakash, Chinnasamy Rajaram
Format Journal Article
LanguageEnglish
Published Riyadh, Saudi Arabia Elsevier B.V 01.01.2015
Saudi Chemical Society
Elsevier
Subjects
Anti-infective agents
Antibacterial activity
Antifungal activity
Quinazolin-4(3H)-one
Schiff base
Semicarbazide
الأدوية
Quinazolin-4(3H)-one
Schiff base
Antifungal activity
Antibacterial activity
Semicarbazide
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Summary:A series of 1-(substitutedbenzylidene)-4-(4-(2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl) phenyl)semicarbazide derivatives were synthesized with the aim of developing potential antimicrobials. It was characterized by FT-IR, 1H NMR, Mass spectroscopy and elemental analysis. In addition, the in vitro antibacterial and antifungal properties were tested against some human pathogenic microorganisms by employing the disc diffusion technique and agar streak dilution method. All title compounds showed activity against the entire strain of microorganisms. The relationship between the functional group variation and the biological activity of the evaluated compounds were well discussed. Based on the results obtained, compound 5j was found to be very active compared to the rest of the compounds which were subjected to antimicrobial assay.
ISSN:1319-6103
DOI:10.1016/j.jscs.2011.12.010