Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair
Over centuries, several advances have been made in osteochondral (OC) tissue engineering to regenerate more biomimetic tissue. As an essential component of tissue engineering, scaffolds provide structural and functional support for cell growth and differentiation. Numerous scaffold types, such as po...
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Published in | Frontiers in bioengineering and biotechnology Vol. 9; p. 812383 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
11.01.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Over centuries, several advances have been made in osteochondral (OC) tissue engineering to regenerate more biomimetic tissue. As an essential component of tissue engineering, scaffolds provide structural and functional support for cell growth and differentiation. Numerous scaffold types, such as porous, hydrogel, fibrous, microsphere, metal, composite and decellularized matrix, have been reported and evaluated for OC tissue regeneration
and
, with respective advantages and disadvantages. Unfortunately, due to the inherent complexity of organizational structure and the objective limitations of manufacturing technologies and biomaterials, we have not yet achieved stable and satisfactory effects of OC defects repair. In this review, we summarize the complicated gradients of natural OC tissue and then discuss various osteochondral tissue engineering strategies, focusing on scaffold design with abundant cell resources, material types, fabrication techniques and functional properties. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Jianxun Ding, Changchun Institute of Applied Chemistry (CAS), China This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology These authors have contributed equally to this work Zhen Yang, Nankai University, China Edited by: Yin Fang, Nanyang Technological University, Singapore Wenguo Cui, Shanghai Jiao Tong University, China Yongliang Ni, Lam Research, United States |
ISSN: | 2296-4185 2296-4185 |
DOI: | 10.3389/fbioe.2021.812383 |