Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair

Over centuries, several advances have been made in osteochondral (OC) tissue engineering to regenerate more biomimetic tissue. As an essential component of tissue engineering, scaffolds provide structural and functional support for cell growth and differentiation. Numerous scaffold types, such as po...

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Published inFrontiers in bioengineering and biotechnology Vol. 9; p. 812383
Main Authors Fu, Jiang-Nan, Wang, Xing, Yang, Meng, Chen, You-Rong, Zhang, Ji-Ying, Deng, Rong-Hui, Zhang, Zi-Ning, Yu, Jia-Kuo, Yuan, Fu-Zhen
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 11.01.2022
Subjects
Bioengineering and Biotechnology
biomaterials
fabrication
osteochondral repair
scaffolds
tissue engineering
osteochondral repair
tissue engineering
scaffolds
biomaterials
fabrication
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Summary:Over centuries, several advances have been made in osteochondral (OC) tissue engineering to regenerate more biomimetic tissue. As an essential component of tissue engineering, scaffolds provide structural and functional support for cell growth and differentiation. Numerous scaffold types, such as porous, hydrogel, fibrous, microsphere, metal, composite and decellularized matrix, have been reported and evaluated for OC tissue regeneration and , with respective advantages and disadvantages. Unfortunately, due to the inherent complexity of organizational structure and the objective limitations of manufacturing technologies and biomaterials, we have not yet achieved stable and satisfactory effects of OC defects repair. In this review, we summarize the complicated gradients of natural OC tissue and then discuss various osteochondral tissue engineering strategies, focusing on scaffold design with abundant cell resources, material types, fabrication techniques and functional properties.
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Reviewed by: Jianxun Ding, Changchun Institute of Applied Chemistry (CAS), China
This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology
These authors have contributed equally to this work
Zhen Yang, Nankai University, China
Edited by: Yin Fang, Nanyang Technological University, Singapore
Wenguo Cui, Shanghai Jiao Tong University, China
Yongliang Ni, Lam Research, United States
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2021.812383