IFITM3 , FURIN , ACE1 , and TNF-α Genetic Association With COVID-19 Outcomes: Systematic Review and Meta-Analysis
Human polymorphisms may contribute to SARS-CoV-2 infection susceptibility and COVID-19 outcomes (asymptomatic presentation, severe COVID-19, death). We aimed to evaluate the association of , , , and genetic variants with both phenotypes using meta-analysis. The bibliographic search was conducted on...
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Published in | Frontiers in genetics Vol. 13; p. 775246 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
01.04.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Human polymorphisms may contribute to SARS-CoV-2 infection susceptibility and COVID-19 outcomes (asymptomatic presentation, severe COVID-19, death). We aimed to evaluate the association of
,
,
, and
genetic variants with both phenotypes using meta-analysis. The bibliographic search was conducted on the PubMed and Scielo databases covering reports published until February 8, 2022. Two independent researchers examined the study quality using the Q-Genie tool. Using the Mantel-Haenszel weighted means method, odds ratios were combined under both fixed- and random-effect models. Twenty-seven studies were included in the systematic review (five with
, two with
, three with
, and 17 with
) and 22 in the meta-analysis (
= 3,
, and
= 16). Meta-analysis indicated no association of 1)
rs4646994 and susceptibility, 2)
rs4646994 and asymptomatic COVID-19, 3)
rs12252 and ICU hospitalization, and 4)
rs1800629 and death. On the other hand, significant results were found for
rs4646994 association with COVID-19 severity (11 studies, 692 severe cases, and 1,433 nonsevere controls). The
rs4646994 deletion allele showed increased odds for severe manifestation (OR: 1.45; 95% CI: 1.26-1.66). The homozygous deletion was a risk factor (OR: 1.49, 95% CI: 1.22-1.83), while homozygous insertion presented a protective effect (OR: 0.57, 95% CI: 0.45-0.74). Further reports are needed to verify this effect on populations with different ethnic backgrounds.
: https://www.crd.york.ac.uk/prosperodisplay_record.php?ID=CRD42021268578, identifier CRD42021268578. |
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Bibliography: | content type line 23 SourceType-Scholarly Journals-1 Edited by: José M. Álvarez-Castro, University of Santiago de Compostela, Spain Gagandeep Kaur, University of Rochester, United States Reviewed by: Martha Guevara-Cruz, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Mexico This article was submitted to Applied Genetic Epidemiology, a section of the journal Frontiers in Genetics |
ISSN: | 1664-8021 1664-8021 |
DOI: | 10.3389/fgene.2022.775246 |