A Comparison of Two Hybrid Closed-Loop Systems in Italian Children and Adults With Type 1 Diabetes

• Published in: Frontiers in endocrinology (Lausanne) Vol. 12; p. 802419
• Main Authors: Bassi, Marta, Teliti, Marsida, Lezzi, Marilea, Iosca, Arianna, Strati, Marina Francesca, Carmisciano, Luca, d’Annunzio, Giuseppe, Minuto, Nicola, Maggi, Davide
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.01.2022
• Subjects: Adolescent; Adult; Aged; AHCL (advanced hybrid closed loop); Blood Glucose - metabolism; Blood Glucose Self-Monitoring; CGM (continuous glucose monitoring); Child; Child, Preschool; CSII (continuous subcutaneous insulin infusion); Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - metabolism; Endocrinology; Female; Glycemic Control - instrumentation; Glycemic Control - methods; Humans; Hypoglycemia - chemically induced; Hypoglycemia - prevention & control; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - adverse effects; Infusion Pumps, Implantable; Insulin - administration & dosage; Insulin - adverse effects; Insulin Infusion Systems; Italy; Male; Middle Aged; Monitoring, Ambulatory; Retrospective Studies; TIR (time in range); type 1 diabetes; Young Adult; Italy; AHCL (advanced hybrid closed loop); type 1 diabetes; CGM (continuous glucose monitoring); TIR (time in range); CSII (continuous subcutaneous insulin infusion)
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2021.802419

Tandem Control-IQ and Minimed 780G represent the most Advanced Hybrid Closed Loop (AHCL) systems currently available in pediatric and adult subjects with Type 1 Diabetes (T1D). We retrospectively compared clinical and continuous glucose monitoring data from 51 patients who upgraded to Minimed 780G system and have completed 1-month observation period with data from 39 patients who upgraded to Tandem Control-IQ. Inverse probability weighting was used to minimize the basal characteristics imbalances. Both AHCL systems showed a significant improvement in glycemic parameters. Minimed 780G group achieved higher TIR increase (p= 0.004) and greater reduction of blood glucose average (p= 0.001). Tandem Control-IQ system significantly reduced the occurrence of TBR (p= 0.010) and the Coefficient of Variation of glucose levels (p= 0.005). The use of ACHL systems led to a significant improvement of glycemic control substantially reaching the International recommended glycemic targets. Minimed 780G appears to be more effective in managing hyperglycemia, while Tandem Control-IQ seems to be more effective in reducing time in hypoglycemia.