Selenium in the Treatment of Graves' Hyperthyroidism and Eye Disease
Based on the role of oxidative stress in the pathogenesis of Graves' hyperthyroidism (GH) and Graves' Orbitopathy (GO), a therapy with the antioxidant agent selenium has been proposed and a number of studies have been performed, both and . In GH, reactive oxygen species (ROS) contribute to...
Saved in:
Published in | Frontiers in endocrinology (Lausanne) Vol. 11; p. 608428 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
26.01.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Based on the role of oxidative stress in the pathogenesis of Graves' hyperthyroidism (GH) and Graves' Orbitopathy (GO), a therapy with the antioxidant agent selenium has been proposed and a number of studies have been performed, both
and
. In GH, reactive oxygen species (ROS) contribute to the thyroid and peripheral tissues damage. In GO, tissue hypoxia, as well as ROS, are involved in the typical changes that occur in fibroadipose orbital tissue and the perimysium of extraocular muscles. Antioxidants have been proposed to improve the effects of antithyroid drugs in GH patients, as well as the remodeling of orbital tissues in patients with GO. Here, we reviewed the literature on the possible beneficial effects and clinical use of selenium in the management of patients with GH and GO. A randomized clinical trial on the use of selenium in patients with mild GO provided evidence for a beneficial effect; no data are available on more severe forms of GO. Although the real effectiveness of selenium in patients with GH remains questionable, its use in the management of mild GO is generally believed to be beneficial, and selenium administration has been included in the clinical practice for the patients with mild eye disease. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Ilaria Muller, Fondazione IRCCS Ospedale Ca ‘Granda Maggiore Policlinico, Italy This article was submitted to Thyroid Endocrinology, a section of the journal Frontiers in Endocrinology Reviewed by: Giampaolo Papi, Local Health Unit of Modena, Italy; Mario Vitale, University of Salerno, Italy |
ISSN: | 1664-2392 1664-2392 |
DOI: | 10.3389/fendo.2020.608428 |