The Utility of Specific Antibodies Against SARS-CoV-2 in Laboratory Diagnosis

The Coronavirus Disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has now become a global pandemic due to its high transmissibility. The unavoidable shortcomings of traditional diagnostic assay, including nucleic acid testing, diverse serological assa...

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Published inFrontiers in microbiology Vol. 11; p. 603058
Main Authors Fu, Yu, Pan, Yunbao, Li, Zhiqiang, Li, Yirong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.01.2021
Subjects
COVID-19
dynamic change
Microbiology
SARS-CoV-2
serological assays
specific antibodies
COVID-19
serological assays
SARS-CoV-2
dynamic change
specific antibodies
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Summary:The Coronavirus Disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has now become a global pandemic due to its high transmissibility. The unavoidable shortcomings of traditional diagnostic assay, including nucleic acid testing, diverse serological assays characterized by high-throughput and less workload, are playing a more and more crucial role to supplement the nucleic acid test. In this review, we summarize the dynamic change of the specific IgM, IgG, and IgA antibodies against SARS-CoV-2 as well as neutralizing antibodies and discuss the clinical utility and limitations of the different serological assays. SARS-CoV-2, a newly discovered virus, shows some unique pathogenetic and epidemiological characteristics that have not been completely understood so far. Currently, studies about the antibody responses against SARS-CoV-2 and the clinical utility of serological testing are increasing. It’s well suggested that the combination of serological tests and nucleic acid tests can cohesively improve the testing efficiency for identifying COVID-19 suspected patients.
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Reviewed by: Kuldeep Dhama, Indian Veterinary Research Institute (IVRI), India; Leticia Cedillo-Barron, Instituto Politécnico Nacional de México (CINVESTAV), Mexico
Edited by: Juarez Antonio Simões Quaresma, Evandro Chagas Institute, Brazil
This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2020.603058