Enzymatic Hydrolysis of Tetriso as a Model for the Detoxication of the Neurotoxic Agent VX

Researchers are trying to develop detoxication processes for highly toxic compounds such as the VX nerve gas. Using an analog of the VX called Tetriso, researchers have developed a promising detoxication process based on enzymatic hydrolysis. The process involves the insertion of a plasmid from the...

Full description

Saved in:
Bibliographic Details
Published inThe Biological bulletin (Lancaster) Vol. 187; no. 2; pp. 249 - 250
Main Authors Hoskin, F. C. G., Walker, J. E.
Format Journal Article
LanguageEnglish
Published United States Marine Biological Laboratory 01.10.1994
University of Chicago Press
Subjects
Cholinesterase Inhibitors - metabolism
Hydrolases - metabolism
Inactivation, Metabolic
Models, Biological
Nerve agents
Nerve gas
Organic phosphorus compounds
Organophosphorus compounds
Organophosphorus Compounds - metabolism
Organothiophosphorus Compounds - metabolism
Physiological aspects
Pseudomonas - enzymology
Online AccessGet full text

Cover

More Information
Summary:Researchers are trying to develop detoxication processes for highly toxic compounds such as the VX nerve gas. Using an analog of the VX called Tetriso, researchers have developed a promising detoxication process based on enzymatic hydrolysis. The process involves the insertion of a plasmid from the Pseudomonas diminuta into an E.coli growth to the late log or early stationary phase and subjecting the growth to organophosphorous hydrodase activity.
ISSN:0006-3185
1939-8697
DOI:10.1086/BBLv187n2p249