GP IIb/IIIa-Mediated Platelet Activation and Its Modulation of the Immune Response of Monocytes Against Candida albicans

is the most common fungal pathogen in humans, causing invasive disease and even potentially life-threatening systemic infections when tissue homeostasis is disrupted. Previous studies have identified an essential role of platelets in infection and immunity, especially when they are activated. Howeve...

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Published inFrontiers in cellular and infection microbiology Vol. 11; p. 783085
Main Authors Zheng, Lin, Duan, Zhimin, Tang, Dingjie, He, Yanzhi, Chen, Xu, Chen, Qing, Li, Min
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.12.2021
Subjects
Blood Platelets - immunology
Candida albicans
Cells, Cultured
Cellular and Infection Microbiology
GP IIb/IIIa
Humans
monocytes
Monocytes - immunology
Phosphatidylinositol 3-Kinases
PI3K/AKT
Platelet Activation
Platelet Glycoprotein GPIIb-IIIa Complex - immunology
platelets
Proto-Oncogene Proteins c-akt
Candida albicans
monocytes
GP IIb/IIIa
platelets
PI3K/AKT
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Summary:is the most common fungal pathogen in humans, causing invasive disease and even potentially life-threatening systemic infections when tissue homeostasis is disrupted. Previous studies have identified an essential role of platelets in infection and immunity, especially when they are activated. However, it is still unclear whether platelets can be activated by , and even less is known about the role of platelets in infection. Herein, we showed that induced platelet activation . elevated the levels of AKT Ser473 phosphorylation, and inhibition of the PI3K-AKT signaling pathway reversed -induced platelet activation. Surprisingly, -induced platelet activation occurred in an integrin glycoprotein (GP) IIb/IIIa-dependent manner but was independent of the pattern recognition receptors toll-like receptor (TLR) 2 and TLR4. Interestingly, platelets enhanced the phagocytosis of human monocytes challenged with and upregulated the expression of inflammatory cytokines, which were dependent on platelet activation mediated by GP IIb/IIIa. The present work provides new insights into the role of activated platelets in the defense against , highlighting the importance of GP IIb/IIIa in the recognition of .
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Edited by: Stefan Oehlers, Royal Prince Alfred Hospital, Australia
Reviewed by: Elinor Hortle, Royal Prince Alfred Hospital, Australia; Zhichao Fan, UCONN Health, United States
This article was submitted to Microbes and Innate Immunity, a section of the journal Frontiers in Cellular and Infection Microbiology
These authors have contributed equally to this work and share the last authorship
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2021.783085