Raman spectroscopy: A prospective intraoperative visualization technique for gliomas

The infiltrative growth and malignant biological behavior of glioma make it one of the most challenging malignant tumors in the brain, and how to maximize the extent of resection (EOR) while minimizing the impact on normal brain tissue is the pursuit of neurosurgeons. The current intraoperative visu...

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Published inFrontiers in oncology Vol. 12; p. 1086643
Main Authors Zhang, Yi, Yu, Hongquan, Li, Yunqian, Xu, Haiyang, Yang, Liu, Shan, Peilin, Du, Yuejiao, Yan, Xiaokai, Chen, Xuan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.01.2023
Subjects
EOR
glioma
intraoperative
Oncology
Raman spectroscopy
SERS
SRH
intraoperative
SRH
EOR
glioma
Raman spectroscopy
SERS
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Summary:The infiltrative growth and malignant biological behavior of glioma make it one of the most challenging malignant tumors in the brain, and how to maximize the extent of resection (EOR) while minimizing the impact on normal brain tissue is the pursuit of neurosurgeons. The current intraoperative visualization assistance techniques applied in clinical practice suffer from low specificity, slow detection speed and low accuracy, while Raman spectroscopy (RS) is a novel spectroscopy technique gradually developed and applied to clinical practice in recent years, which has the advantages of being non-destructive, rapid and accurate at the same time, allowing excellent intraoperative identification of gliomas. In the present work, the latest research on Raman spectroscopy in glioma is summarized to explore the prospect of Raman spectroscopy in glioma surgery.
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Reviewed by: Mitchel Berger, University of California, San Francisco, United States; Xiaolei Chen, People’s Liberation Army General Hospital, China
Edited by: Zhifeng Shi, Fudan University, China
These authors have contributed equally to this work
This article was submitted to Neuro-Oncology and Neurosurgical Oncology, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.1086643