Deep Brain Stimulation Initiative: Toward Innovative Technology, New Disease Indications, and Approaches to Current and Future Clinical Challenges in Neuromodulation Therapy

Deep brain stimulation (DBS) is one of the most important clinical therapies for neurological disorders. DBS also has great potential to become a great tool for clinical neuroscience research. Recently, the National Engineering Laboratory for Neuromodulation at Tsinghua University held an internatio...

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Published inFrontiers in neurology Vol. 11; p. 597451
Main Authors Sui, Yanan, Tian, Ye, Ko, Wai Kin Daniel, Wang, Zhiyan, Jia, Fumin, Horn, Andreas, De Ridder, Dirk, Choi, Ki Sueng, Bari, Ausaf A, Wang, Shouyan, Hamani, Clement, Baker, Kenneth B, Machado, Andre G, Aziz, Tipu Z, Fonoff, Erich Talamoni, Kühn, Andrea A, Bergman, Hagai, Sanger, Terence, Liu, Hesheng, Haber, Suzanne N, Li, Luming
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 28.01.2021
Subjects
deep brain stimulation
depression
gait disability
MRI compatibility
Neurology
neuromoxdulation
gait disability
depression
neuromoxdulation
MRI compatibility
deep brain stimulation
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Summary:Deep brain stimulation (DBS) is one of the most important clinical therapies for neurological disorders. DBS also has great potential to become a great tool for clinical neuroscience research. Recently, the National Engineering Laboratory for Neuromodulation at Tsinghua University held an international Deep Brain Stimulation Initiative workshop to discuss the cutting-edge technological achievements and clinical applications of DBS. We specifically addressed new clinical approaches and challenges in DBS for movement disorders (Parkinson's disease and dystonia), clinical application toward neurorehabilitation for stroke, and the progress and challenges toward DBS for neuropsychiatric disorders. This review highlighted key developments in (1) neuroimaging, with advancements in 3-Tesla magnetic resonance imaging DBS compatibility for exploration of brain network mechanisms; (2) novel DBS recording capabilities for uncovering disease pathophysiology; and (3) overcoming global healthcare burdens with online-based DBS programming technology for connecting patient communities. The successful event marks a milestone for global collaborative opportunities in clinical development of neuromodulation to treat major neurological disorders.
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Edited by: Vitor Engracia Valenti, São Paulo State University, Brazil
This article was submitted to Autonomic Neuroscience, a section of the journal Frontiers in Neurology
These authors have contributed equally to this work
Reviewed by: Stephen Tisch, St Vincent's Hospital Sydney, Australia; Ron Alterman, Beth Israel Deaconess Medical Center and Harvard Medical School, United States; Laura Cif, University Hospital Montpellier, Montpellier, France; Luigi M. Romito, Fondazione IRCCS Istituto Neurologio Carlo Besta, Italy
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2020.597451