Nasal Septum Deviation as the Consequence of BMP-Controlled Changes to Cartilage Properties

The nasal septum cartilage is a specialized hyaline cartilage important for normal midfacial growth. Abnormal midfacial growth is associated with midfacial hypoplasia and nasal septum deviation (NSD). However, the underlying genetics and associated functional consequences of these two anomalies are...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 696545
Main Authors Baddam, Pranidhi, Young, Daniel, Dunsmore, Garett, Nie, Chunpeng, Eaton, Farah, Elahi, Shokrollah, Jovel, Juan, Adesida, Adetola B, Dufour, Antoine, Graf, Daniel
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.06.2021
Subjects
BMP2
BMP7
Cell and Developmental Biology
elastic cartilage
hyaline cartilage
nasal septum deviation
Wnt signaling
BMP2
Wnt signaling
elastic cartilage
nasal septum deviation
chondrocyte properties
BMP7
glucose metabolism
hyaline cartilage
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Summary:The nasal septum cartilage is a specialized hyaline cartilage important for normal midfacial growth. Abnormal midfacial growth is associated with midfacial hypoplasia and nasal septum deviation (NSD). However, the underlying genetics and associated functional consequences of these two anomalies are poorly understood. We have previously shown that loss of Bone Morphogenetic Protein 7 (BMP7) from neural crest (BMP7 ) leads to midfacial hypoplasia and subsequent septum deviation. In this study we elucidate the cellular and molecular abnormalities underlying NSD using comparative gene expression, quantitative proteomics, and immunofluorescence analysis. We show that reduced cartilage growth and septum deviation are associated with acquisition of elastic cartilage markers and share similarities with osteoarthritis (OA) of the knee. The genetic reduction of BMP2 in BMP7 mice was sufficient to rescue NSD and suppress elastic cartilage markers. To our knowledge this investigation provides the first genetic example of an cartilage fate switch showing that this is controlled by the relative balance of BMP2 and BMP7. Cellular and molecular changes similar between NSD and knee OA suggest a related etiology underlying these cartilage abnormalities.
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ORCID: Pranidhi Baddam, orcid.org/0000-0003-0232-2022; Daniel Young, orcid.org/0000-0003-2542-0135; Garret Dunsmore, orcid.org/0000-0002-5170-9533; Chunpeng Nie, orcid.org/0000-0003-3295-0943; Farah Eaton, orcid.org/0000-0002-8251-8908; Shokrollah Elahi, orcid.org/0000-0002-7215-2009; Juan Jovel, orcid.org/0000-0003-4557-6380; Adetola B. Adesida, orcid.org/0000-0003-1798-6251; Antoine Dufour, orcid.org/0000-0002-3429-4188; Daniel Graf, orcid.org/0000-0003-1163-8117
Edited by: Hang Lin, University of Pittsburgh, United States
Reviewed by: Yuji Mishina, University of Michigan, United States; Susan W. Herring, University of Washington, United States
Present address: Garett Dunsmore, INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France
This article was submitted to Stem Cell Research, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.696545