Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers

• Published in: Frontiers in immunology Vol. 12; p. 681810
• Main Authors: Meng, Leilei, Song, Zichen, Liu, Anding, Dahmen, Uta, Yang, Xiao, Fang, Haoshu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.07.2021
• Subjects: Acute-Phase Proteins - genetics; Acute-Phase Proteins - metabolism; Alleles; Animals; Carrier Proteins - genetics; Carrier Proteins - metabolism; Communicable Diseases - etiology; Communicable Diseases - metabolism; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Immunology; infections; inflammation; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; inflammatory diseases; lipopolysaccharide-binding protein; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Metabolic Diseases - diagnosis; Metabolic Diseases - genetics; Metabolic Diseases - metabolism; metabolic disorders; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Polymorphism, Single Nucleotide; single nucleotide polymorphisms; metabolic disorders; inflammation; cancers; infections; lipopolysaccharide-binding protein; inflammatory diseases; single nucleotide polymorphisms
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2021.681810

Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers.