Cytotoxic T-Cell Trafficking Chemokine Profiles Correlate With Defined Mucosal Microbial Communities in Colorectal Cancer

• Published in: Frontiers in immunology Vol. 12; p. 715559
• Main Authors: Zhang, Jiali, Tao, Ji, Gao, Ruo-Nan, Wei, Zhi-Yuan, He, Yu-Shan, Ren, Chun-Yan, Li, Qi-Chun, Liu, Yan-Shan, Wang, Ke-Wei, Yang, Gong, Qian, Chengjia, Chen, Jian-Huan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.09.2021
• Subjects: adjacent normal tissues; Adult; Aged; Biomarkers; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; chemokines; Chemokines - metabolism; Chemotaxis, Leukocyte - immunology; colorectal cancer; Colorectal Neoplasms - etiology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Computational Biology - methods; Disease Progression; Disease Susceptibility; Female; Fluorescent Antibody Technique; Gastrointestinal Microbiome - immunology; Humans; Immunohistochemistry; Immunology; Male; Metagenome; Metagenomics; Middle Aged; mucosa-associated bacteria; Neoplasm Grading; Neoplasm Staging; T cell trafficking; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Cytotoxic - metabolism; tumor; colorectal cancer; mucosa-associated bacteria; T cell trafficking; adjacent normal tissues; chemokines; tumor

The involvement of gut microbiota in T-cell trafficking into tumor tissue of colorectal cancer (CRC) remains to be further elucidated. The current study aimed to evaluate the expression of major cytotoxic T-cell trafficking chemokines (CTTCs) and chemokine-associated microbiota profiles in both tumo...