Targeting the Gut Microbiota in Chagas Disease: What Do We Know so Far?

Chagas disease (CD) is a tropical and still neglected disease caused by that affects >8 million of people worldwide. Although limited, emerging data suggest that gut microbiota dysfunction may be a new mechanism underlying CD pathogenesis. infection leads to changes in the gut microbiota composit...

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Published inFrontiers in microbiology Vol. 11; p. 585857
Main Authors Duarte-Silva, Eduardo, Morais, Livia H, Clarke, Gerard, Savino, Wilson, Peixoto, Christina
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.12.2020
Subjects
Chagas disease
gut microbiota
Microbiology
prebiotics
probiotics
Trypanosoma cruzi
Chagas disease
prebiotics
gut microbiota
Trypanosoma cruzi
probiotics
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Summary:Chagas disease (CD) is a tropical and still neglected disease caused by that affects >8 million of people worldwide. Although limited, emerging data suggest that gut microbiota dysfunction may be a new mechanism underlying CD pathogenesis. infection leads to changes in the gut microbiota composition of vector insects, mice, and humans. Alterations in insect and mice microbiota due to have been associated with a decreased immune response against the parasite, influencing the establishment and progression of infection. Further, changes in the gut microbiota are linked with inflammatory and neuropsychiatric disorders, comorbid conditions in CD. Therefore, this review article critically analyses the current data on CD and the gut microbiota of insects, mice, and humans and discusses its importance for CD pathogenesis. An enhanced understanding of host microbiota will be critical for the development of alternative therapeutic approaches to target CD, such as gut microbiota-directed interventions.
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This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology
Edited by: Takahiro Masuda, Kyushu University, Japan
Reviewed by: Marisa Mariel Fernandez, Institute of Studies on Humoral Immunity (IDEHU), Argentina; Thomas Jacobs, Bernhard Nocht Institute for Tropical Medicine (BMITM), Germany
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2020.585857