Arnica Montana L. Supercritical Extraction Optimization for Antibiotic and Anticancer Activity

L. flower heads are known for their antioxidant, antimicrobial, and anticancer activity. The aim of this work was to optimize the process of supercritical CO extraction, to achieve high extraction yield and high content of biologically active components, and to confirm the antimicrobial and anticanc...

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Published inFrontiers in bioengineering and biotechnology Vol. 10; p. 897185
Main Authors Žitek, Taja, Postružnik, Vesna, Knez, Željko, Golle, Andrej, Dariš, Barbara, Knez Marevci, Maša
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.05.2022
Subjects
active ingredients
anticarcinogenic activity
antimicrobial activity
Bioengineering and Biotechnology
mountain arnica
natural extract
mountain arnica
natural extract
active ingredients
antimicrobial activity
anticarcinogenic activity
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Summary:L. flower heads are known for their antioxidant, antimicrobial, and anticancer activity. The aim of this work was to optimize the process of supercritical CO extraction, to achieve high extraction yield and high content of biologically active components, and to confirm the antimicrobial and anticancer activity of the extract. The influence of pressure and temperature on the total phenolic content, antioxidant activity, and proanthocyanidin content was evaluated. The pressure and temperature were found to be interdependent. A temperature of 60°C and a pressure of 30 MPa resulted in a high extraction yield, antioxidant activity and phenolic content. The content of proanthocyanidins was highest at a pressure between 18 and 24 MPa. The extracts inhibited three different microorganisms successfully; and , at concentrations ranging from 0.1 to 5.16 mg/ml and showed anticancer activity decrease up to 85% at a concentration of 0.5 mg/ml.
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Reviewed by: Giovani Leone Zabot, Federal University of Santa Maria, Brazil
Patrícia Melchionna Albuquerque, University of the State of Amazonas, Brazil
This article was submitted to Industrial Biotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology
Edited by: Lucia Gardossi, University of Trieste, Italy
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.897185