Gut Microbiome and the Role of Metabolites in the Study of Graves' Disease

Graves' disease (GD) is an autoimmune thyroid disease (AITD), which is one of the most common organ-specific autoimmune disorders with an increasing prevalence worldwide. But the etiology of GD is still unclear. A growing number of studies show correlations between gut microbiota and GD. The dy...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in molecular biosciences Vol. 9; p. 841223
Main Authors Liu, Haihua, Liu, Huiying, Liu, Chang, Shang, Mengxue, Wei, Tianfu, Yin, Peiyuan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.02.2022
Subjects
autoimmunity
graves’ disease (GD)
gut microbiome
metabol(n)omics
metabolites
Molecular Biosciences
gut microbiome
metabol(n)omics
autoimmunity
graves’ disease (GD)
metabolites
Online AccessGet full text

Cover

More Information
Summary:Graves' disease (GD) is an autoimmune thyroid disease (AITD), which is one of the most common organ-specific autoimmune disorders with an increasing prevalence worldwide. But the etiology of GD is still unclear. A growing number of studies show correlations between gut microbiota and GD. The dysbiosis of gut microbiota may be the reason for the development of GD by modulating the immune system. Metabolites act as mediators or modulators between gut microbiota and thyroid. The purpose of this review is to summarize the correlations between gut microbiota, microbial metabolites and GD. Challenges in the future study are also discussed. The combination of microbiome and metabolome may provide new insight for the study and put forward the diagnosis, treatment, prevention of GD in the future.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Thomas Kaiser, University of Minnesota Twin Cities, United States
Edited by: Wolfram Weckwerth, University of Vienna, Austria
This article was submitted to Metabolomics, a section of the journal Frontiers in Molecular Biosciences
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2022.841223