Fibroadenoma and intraduct papilloma—a common pathogenesis?

• Published in: Virchows Archiv : an international journal of pathology Vol. 455; no. 3; pp. 271 - 275
• Main Authors: Cummings, Margaret C., da Silva, Leonard, Papadimos, David J., Lakhani, Sunil R.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.09.2009; Springer; Springer Nature B.V
• Subjects: Adolescent; Biological and medical sciences; Breast Neoplasms - etiology; Breast Neoplasms - pathology; Case Report; Female; Fibroadenoma - etiology; Fibroadenoma - pathology; Gynecology. Andrology. Obstetrics; Humans; Investigative techniques, diagnostic techniques (general aspects); Ki-67 Antigen - analysis; Mammary gland diseases; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Papilloma, Intraductal - etiology; Papilloma, Intraductal - pathology; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Tumors; Pathogenesis; Fibroadenoma; Intraduct papilloma; Papilloma; Anatomic pathology; Benign neoplasm
• ISSN: 0945-6317; 1432-2307
• DOI: 10.1007/s00428-009-0817-8

This report describes two cases, each showing fibroepithelial proliferation, admixed with intraduct papillomas. Case 1 was from a 13-year-old female who presented with a breast mass, while case 2 was from a 60-year-old female who also had a breast lump. Case 1 showed proliferative breast disease with multiple small papillomas, some with leaf-like contours. Broad-based parenchymal proliferations protruding into ducts were also seen, and there were overlap features between the two ends of this spectrum. Case 2, similarly, demonstrated a mixed intraductal proliferation, with papillomas on narrow stalks together with low-grade phyllode areas extending into ducts from a wider base. That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed.