Long-term olive oil-based parenteral nutrition sustains innate immune function in home patients without active underlying disease

• Published in: Clinical nutrition (Edinburgh, Scotland) Vol. 32; no. 4; pp. 643 - 649
• Main Authors: Olthof, E.D, Roelofs, H.M.J, Versleijen, M.W.J, te Morsche, R.H.M, Simonetti, E.R, Hermans, P.W.M, Wanten, G.J.A
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.08.2013; Elsevier
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antigens, CD - metabolism; Antioxidants - metabolism; ascorbic acid; Ascorbic Acid - blood; Biological and medical sciences; Biomarkers - blood; CD11b Antigen - metabolism; Cell Adhesion Molecules - metabolism; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition; emulsions; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; glutathione; Glutathione Disulfide - blood; GPI-Linked Proteins - metabolism; Granulocytes - immunology; Home parenteral nutrition; Humans; Immunity, Innate; Innate immune function; Intensive care medicine; L-Selectin - metabolism; Lipid Peroxidation - drug effects; Male; Medical sciences; Middle Aged; monocytes; Monocytes - immunology; neutrophils; Neutrophils - immunology; Olive Oil; olives; oxidants; parenteral feeding; Parenteral Nutrition, Home; patients; Plant Oils - administration & dosage; reactive oxygen species; risk; Risk Factors; selenium; Selenium - blood; Soybean Oil - administration & dosage; Streptococcus pneumoniae; Vertebrates: anatomy and physiology, studies on body, several organs or systems; ferric reducing ability of plasma; ALP; phorbol 12-myristate 13-acetate; alanine aminotransferase; ALT; Home parenteral nutrition; MDA; Innate immune function; coconut oil; BSA; S. pneumoniae; hank’s buffered salt solution; STZ; olive oil; gamma-glutamyltransferase; alkaline phosphatase; malondialdehyde; CRBSI; serum-treated zymosan particles; fish oil; TBARS; PBMC; Streptococcus pneumoniae; Gamma-GT; PCA; perchloric acid; FA; bovine serum albumin; ELISA; HPN; FO; enzyme linked immunosorbent assay; OPKA; parenteral nutrition; FRAP; SO; OO; peripheral blood mononuclear cells; AST; fatty acids; PMA; soybean oil; thiobarbituric acid reactive substances; catheter-related bloodstream infections; CO; aspartate aminotransferase; opsonophagocytic killing assay; HBSS; PN; Human; Etiology; Metabolic diseases; Parenteral nutrition; Olive oil; Immunity; Long term; Parenteral administration
• ISSN: 0261-5614; 1532-1983
• DOI: 10.1016/j.clnu.2012.08.009

Summary Background & aims It remains unclear whether impaired host defenses contribute to the increased risk for infectious complications seen in patients on home parenteral nutrition (HPN). The aim of this study was to compare the innate immune function of patients on olive oil-based HPN with that of healthy controls. Methods Innate immune functions and (anti-)oxidant balance were studied in 20 patients on olive oil-based HPN without an active underlying immune-mediated disease (Clinoleic® , ≥6 months; >3 times/week), and 21 age- and sex-matched healthy controls. Results Neutrophils of patients and controls had a similar capacity to eliminate Streptococcus pneumoniae . Also, levels of activation markers (CD66b, CD11b, CD62L) in granulocytes and monocytes, phorbol ester- and zymosan-induced neutrophil oxygen radical production were not different between patients and controls. No differences in (anti-)oxidant status were found, except for higher concentrations of oxidized glutathione and lower plasma selenium and vitamin C in patients compared to controls. Conclusion Compromised innate immune function does not seem to explain the increased risk for infectious complications in HPN patients using olive oil-based lipid emulsions.