A magnetic adsorbent grafted with pendant naphthyl polymer brush for enrichment of the nonsteroidal anti-inflammatory drugs indomethacin and diclofenac

• Published in: Mikrochimica acta (1966) Vol. 185; no. 8; pp. 370 - 8
• Main Authors: Deng, Ya’nan, Shen, Jiwei, Liu, Jiawei, Wei, Yinmao, Wang, Chaozhan
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.08.2018; Springer; Springer Nature B.V
• Subjects: Adsorbents; Adsorption; Analysis; Analytic Sample Preparation Methods - methods; Analytical Chemistry; Anti-Inflammatory Agents, Non-Steroidal - analysis; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chromatography, High Pressure Liquid; Diclofenac; Diclofenac - analysis; Diclofenac - isolation & purification; Drugs; Ethylenediaminetetraacetic acid; Extraction processes; Indomethacin; Indomethacin - analysis; Indomethacin - isolation & purification; Jewelry; Magnetite Nanoparticles - chemistry; Microengineering; Nanochemistry; Nanotechnology; Naphthalenes - chemistry; Nonsteroidal anti-inflammatory drugs; Original Paper; Polymer industry; Polymerization; Polymers; Polymers - chemistry; Silica; Silicon dioxide; Silicon Dioxide - chemistry; Solid Phase Extraction; Enrichment; Surface modification; Reversed-phase adsorbents; π- interaction; Adsorption; NSAIDs; Atom transfer radical polymerization; Hydrophobic interaction; Silica coating; Magnetic solid phase extraction
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-018-2913-4

Poly(2-naphthyl acrylate) was first grafted onto silica-coated magnetic nanoparticles by surface-initiated atom transfer radical polymerization to prepare a reversed-phase magnetic adsorbent. The resulting polymer brush displays enhanced extraction efficiency by offering active sites on the surfaces of adsorbent. It was applied to the preconcentration of the non-steroidal antiinflammatory drugs (NSAIDs) indomethacin (InDo) and diclofenac (DIC). These drugs interact with the sorbent through hydrophobic and π-interactions, and via electrostatic attraction. By coupling the magnetic solid-phase extraction with HPLC, a method for analysis of InDo and DIC in the environmental water samples was established. The limits of detection range from 0.62 to 0.64 ng·mL −1 , and the relative standard deviations for intra-and inter-day analyses of spiked water samples are <11.9%, and relative recoveries are between 62.1 and 96.7%. Graphical abstract A reversed-phase magnetic adsorbent was prepared by grafting poly(2-naphthyl acrylate) brush on the surface of silica coated magnetic nanoparticles. Due to the two conjugated aromatic rings of the monomer, the polymer brush can effectively extract non-steroidal anti-inflammatory drugs through strong π- and hydrophobic interactions.