The Role of Forkhead Box Family in Bone Metabolism and Diseases

Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease. Fox family genes are involved in cell differentiation, proliferation and apoptosis, embryonic development, aging, glucose and...

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Published inFrontiers in pharmacology Vol. 12; p. 772237
Main Authors Xu, Jianxiang, Wang, Kanbin, Zhang, Zengjie, Xue, Deting, Li, Weixu, Pan, Zhijun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 28.01.2022
Subjects
bone diseases
bone metabolism
Fox factors-based therapeutics
Fox family
Pharmacology
signaling pathways
Fox family
bone diseases
bone metabolism
signaling pathways
Fox factors-based therapeutics
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Summary:Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease. Fox family genes are involved in cell differentiation, proliferation and apoptosis, embryonic development, aging, glucose and lipid metabolism, and immune regulation. The regulatory role of the Fox family in the context of bone metabolism and orthopedic diseases is an emerging research hotspot. In this review, we highlight the major molecular mechanisms underlying the regulatory role of Fox factors in bone metabolism, bone development, bone homeostasis, and bone diseases associated with inhibition or upregulation of Fox factors. In addition, we discuss the emerging evidence in the realm of Fox factor-based therapeutics.
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Reviewed by: Hanjun Li, Shanghai Jiao Tong University, China
Stefan Koch, Linköping University, Sweden
These authors share first authorship
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
Matteo Barberis, University of Surrey, United Kingdom
Edited by: Rosa Bacchetta, Stanford University, United States
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.772237