Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk

Quorum-sensing (QS) system is a rapidly developing field in which we are gradually expanding our understanding about how bacteria communicate with each other and regulate their activities in bacterial sociality. In addition to collectively modifying bacterial behavior, QS-related autoinducers may al...

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Published inFrontiers in microbiology Vol. 12; p. 611413
Main Authors Wu, Liang, Luo, Yubin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 28.01.2021
Subjects
autoinducers
bacterial communication
host cells
metabolites
Microbiology
quorum sensing
host cells
quorum sensing
bacterial communication
autoinducers
metabolites
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Summary:Quorum-sensing (QS) system is a rapidly developing field in which we are gradually expanding our understanding about how bacteria communicate with each other and regulate their activities in bacterial sociality. In addition to collectively modifying bacterial behavior, QS-related autoinducers may also be embedded in the crosstalk between host and parasitic microbes. In this review, we summarize current studies on QS in the intestinal microbiome field and its potential role in maintaining homeostasis under physiological conditions. Additionally, we outline the canonical autoinducers and their related QS signal-response systems by which several pathogens interact with the host under pathological conditions, with the goal of better understanding intestinal bacterial sociality and facilitating novel antimicrobial therapeutic strategies.
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This article was submitted to Microbial Symbioses, a section of the journal Frontiers in Microbiology
Reviewed by: Randy Ortiz-Castro, National Council of Science and Technology (CONACYT), Mexico; Gregory F. Payne, University of Maryland, College Park, United States
Edited by: Robert Czajkowski, University of Gdańsk, Poland
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.611413