Overexpression of Global Regulator Talae1 Leads to the Discovery of New Antifungal Polyketides From Endophytic Fungus Trichoderma afroharzianum

• Published in: Frontiers in microbiology Vol. 11; p. 622785
• Main Authors: Ding, Zhuang, Wang, Xiao, Kong, Fan-Dong, Huang, Hui-Ming, Zhao, Yan-Na, Liu, Min, Wang, Zheng-Ping, Han, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.12.2020
• Subjects: antifungal activity; endophytic fungi; global regulator; LaeA; Microbiology; polyketides; Trichoderma afroharzianum; Trichoderma afroharzianum; global regulator; polyketides; LaeA; antifungal activity; endophytic fungi

Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a Ficus elastica -associated fungus Trichoderma afroharzianum , two structurally new polyketides ( 1 and 2 ) that were newly produced in t...