Overexpression of Global Regulator Talae1 Leads to the Discovery of New Antifungal Polyketides From Endophytic Fungus Trichoderma afroharzianum
Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a Ficus elastica -associated fungus Trichoderma afroharzianum , two structurally new polyketides ( 1 and 2 ) that were newly produced in t...
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| Published in | Frontiers in microbiology Vol. 11; p. 622785 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Frontiers Media S.A
23.12.2020
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| Abstract | Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a
Ficus elastica
-associated fungus
Trichoderma afroharzianum
, two structurally new polyketides (
1
and
2
) that were newly produced in the transformant were isolated and identified. Their structures, including the absolute configurations, were elucidated through a combination of high resolution mass spectrometer (HRMS), NMR, and electronic circular dichroism (ECD) calculations. The growth inhibitory activities of compounds
1
and
2
were evaluated against four bacteria and six plant-pathogenic fungi. Compound
1
showed the highest antifungal activity against
Botrytis cinerea
and
Fusarium oxysporum
f. sp.
nicotianae
with MIC of 8 μg/ml. To the best of our knowledge, this is the first study to report on the application of the global regulator in
T. afroharzianum
to activate the biosynthesis of bioactive secondary metabolites. |
|---|---|
| AbstractList | Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a
Ficus elastica
-associated fungus
Trichoderma afroharzianum
, two structurally new polyketides (
1
and
2
) that were newly produced in the transformant were isolated and identified. Their structures, including the absolute configurations, were elucidated through a combination of high resolution mass spectrometer (HRMS), NMR, and electronic circular dichroism (ECD) calculations. The growth inhibitory activities of compounds
1
and
2
were evaluated against four bacteria and six plant-pathogenic fungi. Compound
1
showed the highest antifungal activity against
Botrytis cinerea
and
Fusarium oxysporum
f. sp.
nicotianae
with MIC of 8 μg/ml. To the best of our knowledge, this is the first study to report on the application of the global regulator in
T. afroharzianum
to activate the biosynthesis of bioactive secondary metabolites. Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a Ficus elastica-associated fungus Trichoderma afroharzianum, two structurally new polyketides (1 and 2) that were newly produced in the transformant were isolated and identified. Their structures, including the absolute configurations, were elucidated through a combination of high resolution mass spectrometer (HRMS), NMR, and electronic circular dichroism (ECD) calculations. The growth inhibitory activities of compounds 1 and 2 were evaluated against four bacteria and six plant-pathogenic fungi. Compound 1 showed the highest antifungal activity against Botrytis cinerea and Fusarium oxysporum f. sp. nicotianae with MIC of 8 μg/ml. To the best of our knowledge, this is the first study to report on the application of the global regulator in T. afroharzianum to activate the biosynthesis of bioactive secondary metabolites.Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a Ficus elastica-associated fungus Trichoderma afroharzianum, two structurally new polyketides (1 and 2) that were newly produced in the transformant were isolated and identified. Their structures, including the absolute configurations, were elucidated through a combination of high resolution mass spectrometer (HRMS), NMR, and electronic circular dichroism (ECD) calculations. The growth inhibitory activities of compounds 1 and 2 were evaluated against four bacteria and six plant-pathogenic fungi. Compound 1 showed the highest antifungal activity against Botrytis cinerea and Fusarium oxysporum f. sp. nicotianae with MIC of 8 μg/ml. To the best of our knowledge, this is the first study to report on the application of the global regulator in T. afroharzianum to activate the biosynthesis of bioactive secondary metabolites. Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a Ficus elastica-associated fungus Trichoderma afroharzianum, two structurally new polyketides (1 and 2) that were newly produced in the transformant were isolated and identified. Their structures, including the absolute configurations, were elucidated through a combination of high resolution mass spectrometer (HRMS), NMR, and electronic circular dichroism (ECD) calculations. The growth inhibitory activities of compounds 1 and 2 were evaluated against four bacteria and six plant-pathogenic fungi. Compound 1 showed the highest antifungal activity against Botrytis cinerea and Fusarium oxysporum f. sp. nicotianae with MIC of 8 μg/ml. To the best of our knowledge, this is the first study to report on the application of the global regulator in T. afroharzianum to activate the biosynthesis of bioactive secondary metabolites. Transcription regulation caused by global regulators exerts important effects on fungal secondary metabolism. By overexpression of the global regulator Talae1 in a -associated fungus , two structurally new polyketides ( and ) that were newly produced in the transformant were isolated and identified. Their structures, including the absolute configurations, were elucidated through a combination of high resolution mass spectrometer (HRMS), NMR, and electronic circular dichroism (ECD) calculations. The growth inhibitory activities of compounds and were evaluated against four bacteria and six plant-pathogenic fungi. Compound showed the highest antifungal activity against and f. sp. with MIC of 8 μg/ml. To the best of our knowledge, this is the first study to report on the application of the global regulator in to activate the biosynthesis of bioactive secondary metabolites. |
| Author | Kong, Fan-Dong Ding, Zhuang Wang, Zheng-Ping Zhao, Yan-Na Han, Jun Liu, Min Wang, Xiao Huang, Hui-Ming |
| AuthorAffiliation | 1 Institute of BioPharmaceutical Research, Liaocheng University , Liaocheng , China 3 School of Life Sciences, Liaocheng University , Liaocheng , China 2 Hainan Key Laboratory for Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou , China |
| AuthorAffiliation_xml | – name: 1 Institute of BioPharmaceutical Research, Liaocheng University , Liaocheng , China – name: 3 School of Life Sciences, Liaocheng University , Liaocheng , China – name: 2 Hainan Key Laboratory for Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou , China |
| Author_xml | – sequence: 1 givenname: Zhuang surname: Ding fullname: Ding, Zhuang – sequence: 2 givenname: Xiao surname: Wang fullname: Wang, Xiao – sequence: 3 givenname: Fan-Dong surname: Kong fullname: Kong, Fan-Dong – sequence: 4 givenname: Hui-Ming surname: Huang fullname: Huang, Hui-Ming – sequence: 5 givenname: Yan-Na surname: Zhao fullname: Zhao, Yan-Na – sequence: 6 givenname: Min surname: Liu fullname: Liu, Min – sequence: 7 givenname: Zheng-Ping surname: Wang fullname: Wang, Zheng-Ping – sequence: 8 givenname: Jun surname: Han fullname: Han, Jun |
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| Copyright | Copyright © 2020 Ding, Wang, Kong, Huang, Zhao, Liu, Wang and Han. Copyright © 2020 Ding, Wang, Kong, Huang, Zhao, Liu, Wang and Han. 2020 Ding, Wang, Kong, Huang, Zhao, Liu, Wang and Han |
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| Keywords | Trichoderma afroharzianum global regulator polyketides LaeA antifungal activity endophytic fungi |
| Language | English |
| License | Copyright © 2020 Ding, Wang, Kong, Huang, Zhao, Liu, Wang and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Microbiotechnology, a section of the journal Frontiers in Microbiology Reviewed by: Weaam Ebrahim, Mansoura University, Egypt; Liwei Wang, Hangzhou Normal University, China; Chunyuan Li, South China Agricultural University, China Edited by: Paola Angelini, University of Perugia, Italy |
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| SubjectTerms | antifungal activity endophytic fungi global regulator LaeA Microbiology polyketides Trichoderma afroharzianum |
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| Title | Overexpression of Global Regulator Talae1 Leads to the Discovery of New Antifungal Polyketides From Endophytic Fungus Trichoderma afroharzianum |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33424824 https://www.proquest.com/docview/2476852088 https://pubmed.ncbi.nlm.nih.gov/PMC7785522 https://doaj.org/article/5fb74013ce764f979483c63b8b4cd041 |
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