Systems analysis of the prostate transcriptome in African-American men compared with European-American men
African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D supplementation. Twenty-seven male subje...
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| Published in | Pharmacogenomics Vol. 17; no. 10; pp. 1129 - 1143 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Future Medicine Ltd
01.07.2016
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1462-2416 1744-8042 |
| DOI | 10.2217/pgs-2016-0025 |
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| Abstract | African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D
supplementation.
Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D
(4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery.
AA show higher expression of genes associated with immune response and inflammation.
Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D
supplementation. |
|---|---|
| AbstractList | Aim: African–Americans (AA) have increased prostate cancer risk and a greater mortality rate than European–Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D3 supplementation. Patients & methods: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. Results: AA show higher expression of genes associated with immune response and inflammation. Conclusion: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D3 supplementation. African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D supplementation. Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery. AA show higher expression of genes associated with immune response and inflammation. Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D supplementation. |
| Author | Savage, Stephen J Courtney, Sean M Halbert, Chanita Hughes Hardiman, Gary Hollis, Bruce W Smith, Michael T Wilson, Robert C Gattoni-Celli, Sebastiano Hazard, E Starr |
| AuthorAffiliation | 3Library Science and Informatics, Medical University of South Carolina, Charleston, SC, USA 1Department of Medicine & Public Health, Medical University of South Carolina, Charleston, SC, USA 4Department of Urology 9Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA 5Ralph H Johnson VA Medical Center, Charleston, SC, USA 2Center for Genomics Medicine, Medical University of South Carolina, Charleston, SC, USA 6Department of Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA 8Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA 7Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA |
| AuthorAffiliation_xml | – name: 7Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA – name: 2Center for Genomics Medicine, Medical University of South Carolina, Charleston, SC, USA – name: 6Department of Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA – name: 1Department of Medicine & Public Health, Medical University of South Carolina, Charleston, SC, USA – name: 5Ralph H Johnson VA Medical Center, Charleston, SC, USA – name: 9Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA – name: 3Library Science and Informatics, Medical University of South Carolina, Charleston, SC, USA – name: 4Department of Urology – name: 8Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA |
| Author_xml | – sequence: 1 givenname: Gary surname: Hardiman fullname: Hardiman, Gary – sequence: 2 givenname: Stephen J surname: Savage fullname: Savage, Stephen J – sequence: 3 givenname: E Starr surname: Hazard fullname: Hazard, E Starr – sequence: 4 givenname: Robert C surname: Wilson fullname: Wilson, Robert C – sequence: 5 givenname: Sean M surname: Courtney fullname: Courtney, Sean M – sequence: 6 givenname: Michael T surname: Smith fullname: Smith, Michael T – sequence: 7 givenname: Bruce W surname: Hollis fullname: Hollis, Bruce W – sequence: 8 givenname: Chanita Hughes surname: Halbert fullname: Halbert, Chanita Hughes – sequence: 9 givenname: Sebastiano surname: Gattoni-Celli fullname: Gattoni-Celli, Sebastiano |
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| Cites_doi | 10.1093/ajcn/73.2.288 10.1111/j.1525-139X.2005.18403.x 10.1016/j.jsbmb.2012.11.012 10.1038/nprot.2013.099 10.1158/0008-5472.CAN-05-1435 10.3945/ajcn.112.034256 10.1124/mol.108.053660 10.1016/S0090-4295(99)00461-6 10.1158/1055-9965.EPI-14-0522 10.4161/epi.6.8.16536 10.1371/journal.pone.0074712 10.1093/nar/gkp427 10.1158/1055-9965.EPI-14-0115 10.1186/gb-2010-11-10-r106 10.1210/jc.2012-1451 10.1093/carcin/bgl041 10.1101/gr.107920.110 10.1210/me.2005-0106 10.1038/sj.bjc.6602796 10.1200/JCO.2010.30.9880 10.1158/1078-0432.CCR-13-3085 10.1038/nprot.2012.016 10.1002/pros.22911 10.1158/0008-5472.CAN-07-2608 10.1002/jcb.10342 10.1249/MSS.0b013e3181eb9d4d 10.1016/S0003-9861(78)80010-1 10.1093/ajcn/76.1.187 10.1158/1055-9965.EPI-13-1340 10.1001/archderm.1991.04510010104011 10.2217/14622416.10.3.417 10.2217/pgs.14.39 10.1186/1471-2164-9-488 10.3945/ajcn.2008.26182 10.1210/en.2011-1600 10.1186/s13059-014-0550-8 10.1016/S0140-6736(82)90214-8 10.1016/S0090-4295(02)01847-2 10.1002/ijc.21749 |
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| References | e_1_3_5_29_1 Feldman D (e_1_3_5_12_1) 2011 e_1_3_5_28_1 e_1_3_5_27_1 e_1_3_5_26_1 e_1_3_5_25_1 e_1_3_5_24_1 e_1_3_5_23_1 e_1_3_5_22_1 e_1_3_5_44_1 e_1_3_5_45_1 e_1_3_5_46_1 e_1_3_5_47_1 Schwartz GG (e_1_3_5_16_1) 1998; 7 e_1_3_5_3_1 e_1_3_5_2_1 e_1_3_5_40_1 e_1_3_5_41_1 e_1_3_5_42_1 e_1_3_5_9_1 e_1_3_5_21_1 e_1_3_5_8_1 e_1_3_5_4_1 e_1_3_5_7_1 e_1_3_5_6_1 e_1_3_5_17_1 e_1_3_5_39_1 e_1_3_5_38_1 Maclaughlin JA (e_1_3_5_5_1) 1983 e_1_3_5_15_1 e_1_3_5_37_1 e_1_3_5_14_1 e_1_3_5_36_1 e_1_3_5_35_1 e_1_3_5_11_1 e_1_3_5_34_1 e_1_3_5_33_1 Miller GJ (e_1_3_5_13_1) 1992; 52 Krishnan AV (e_1_3_5_20_1) 2011 e_1_3_5_19_1 Zimmers TA (e_1_3_5_43_1) 2005; 23 Barreto AM (e_1_3_5_18_1) 2000; 9 e_1_3_5_32_1 e_1_3_5_10_1 e_1_3_5_31_1 e_1_3_5_30_1 16002434 - Mol Endocrinol. 2005 Nov;19(11):2685-95 16205698 - Br J Cancer. 2005 Oct 31;93(9):1019-23 20979621 - Genome Biol. 2010;11(10):R106 11157326 - Am J Clin Nutr. 2001 Feb;73(2):288-94 24732629 - Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1494-504 25516281 - Genome Biol. 2014;15(12):550 22454149 - Endocrinology. 2012 Jun;153(6):2576-87 21537045 - J Clin Oncol. 2011 Jun 10;29(17):2378-85 22383036 - Nat Protoc. 2012 Mar 01;7(3):562-78 9610788 - Cancer Epidemiol Biomarkers Prev. 1998 May;7(5):391-5 19290791 - Pharmacogenomics. 2009 Mar;10(3):417-33 20736230 - Genome Res. 2010 Oct;20(10):1352-60 16557596 - Int J Cancer. 2006 Sep 1;119(5):1082-7 25327758 - Prostate. 2015 Feb 15;75(3):255-65 209750 - Arch Biochem Biophys. 1978 Jun;188(2):282-6 21725204 - Epigenetics. 2011 Aug;6(8):994-1000 24789033 - Clin Cancer Res. 2014 May 1;20(9):2289-99 18245496 - Cancer Res. 2008 Feb 1;68(3):927-36 1848745 - Arch Dermatol. 1991 Apr;127(4):536-8 16140963 - Cancer Res. 2005 Sep 1;65(17):7917-25 25085836 - Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1484-93 1370648 - Cancer Res. 1992 Feb 1;52(3):515-20 12520532 - J Cell Biochem. 2003 Feb 1;88(2):315-22 24974387 - Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1944-7 15897808 - Shock. 2005 Jun;23(6):543-8 23220550 - J Steroid Biochem Mol Biol. 2013 Jul;136:233-7 22760568 - Am J Clin Nutr. 2012 Aug;96(2):332-6 22508710 - J Clin Endocrinol Metab. 2012 Jul;97(7):2315-24 19465376 - Nucleic Acids Res. 2009 Jul;37(Web Server issue):W305-11 19286836 - Mol Pharmacol. 2009 Jun;75(6):1392-9 24897284 - Pharmacogenomics. 2014 Apr;15(6):759-74 20543748 - Med Sci Sports Exerc. 2011 Feb;43(2):335-43 12081833 - Am J Clin Nutr. 2002 Jul;76(1):187-92 23975260 - Nat Protoc. 2013 Sep;8(9):1765-86 16076349 - Semin Dial. 2005 Jul-Aug;18(4):276-89 19064511 - Am J Clin Nutr. 2008 Dec;88(6):1519-27 16624828 - Carcinogenesis. 2006 Sep;27(9):1883-93 18925949 - BMC Genomics. 2008 Oct 16;9:488 10699616 - Urology. 2000 Mar;55(3):387-90 10750664 - Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):265-70 24069333 - PLoS One. 2013 Sep 17;8(9):e74712 6119494 - Lancet. 1982 Jan 9;1(8263):74-6 12385931 - Urology. 2002 Oct;60(4):670-4 |
| References_xml | – ident: e_1_3_5_8_1 doi: 10.1093/ajcn/73.2.288 – volume: 7 start-page: 391 issue: 5 year: 1998 ident: e_1_3_5_16_1 article-title: Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3 publication-title: Cancer Epidemiol. Biomarkers Prev. – ident: e_1_3_5_28_1 doi: 10.1111/j.1525-139X.2005.18403.x – ident: e_1_3_5_10_1 doi: 10.1016/j.jsbmb.2012.11.012 – ident: e_1_3_5_42_1 doi: 10.1038/nprot.2013.099 – ident: e_1_3_5_21_1 doi: 10.1158/0008-5472.CAN-05-1435 – ident: e_1_3_5_9_1 doi: 10.3945/ajcn.112.034256 – ident: e_1_3_5_15_1 doi: 10.1124/mol.108.053660 – ident: e_1_3_5_3_1 doi: 10.1016/S0090-4295(99)00461-6 – ident: e_1_3_5_31_1 doi: 10.1158/1055-9965.EPI-14-0522 – ident: e_1_3_5_17_1 doi: 10.4161/epi.6.8.16536 – ident: e_1_3_5_37_1 doi: 10.1371/journal.pone.0074712 – ident: e_1_3_5_39_1 doi: 10.1093/nar/gkp427 – ident: e_1_3_5_32_1 doi: 10.1158/1055-9965.EPI-14-0115 – ident: e_1_3_5_41_1 doi: 10.1186/gb-2010-11-10-r106 – start-page: 1675 volume-title: Vitamin D (Third Edition) year: 2011 ident: e_1_3_5_20_1 – ident: e_1_3_5_34_1 doi: 10.1210/jc.2012-1451 – ident: e_1_3_5_23_1 doi: 10.1093/carcin/bgl041 – ident: e_1_3_5_26_1 doi: 10.1101/gr.107920.110 – ident: e_1_3_5_25_1 doi: 10.1210/me.2005-0106 – ident: e_1_3_5_24_1 doi: 10.1038/sj.bjc.6602796 – volume-title: Biochemistry and Physiology of the Skin year: 1983 ident: e_1_3_5_5_1 – volume: 23 start-page: 543 issue: 6 year: 2005 ident: e_1_3_5_43_1 article-title: Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury publication-title: Shock (GA, USA) – ident: e_1_3_5_14_1 doi: 10.1200/JCO.2010.30.9880 – ident: e_1_3_5_46_1 doi: 10.1158/1078-0432.CCR-13-3085 – volume: 9 start-page: 265 issue: 3 year: 2000 ident: e_1_3_5_18_1 article-title: 25-Hydroxyvitamin D3, the prohormone of 1,25-dihydroxyvitamin D3, inhibits the proliferation of primary prostatic epithelial cells publication-title: Cancer Epidemiol. Biomarkers Prev. – ident: e_1_3_5_35_1 doi: 10.1038/nprot.2012.016 – ident: e_1_3_5_44_1 doi: 10.1002/pros.22911 – ident: e_1_3_5_45_1 doi: 10.1158/0008-5472.CAN-07-2608 – volume: 52 start-page: 515 issue: 3 year: 1992 ident: e_1_3_5_13_1 article-title: The human prostatic carcinoma cell line LNCaP expresses biologically active, specific receptors for 1 alpha,25-dihydroxyvitamin D3 publication-title: Cancer Res. – ident: e_1_3_5_19_1 doi: 10.1002/jcb.10342 – ident: e_1_3_5_11_1 doi: 10.1249/MSS.0b013e3181eb9d4d – ident: e_1_3_5_4_1 doi: 10.1016/S0003-9861(78)80010-1 – ident: e_1_3_5_29_1 doi: 10.1093/ajcn/76.1.187 – ident: e_1_3_5_33_1 doi: 10.1158/1055-9965.EPI-13-1340 – ident: e_1_3_5_6_1 doi: 10.1001/archderm.1991.04510010104011 – ident: e_1_3_5_27_1 doi: 10.2217/14622416.10.3.417 – ident: e_1_3_5_38_1 doi: 10.2217/pgs.14.39 – ident: e_1_3_5_40_1 doi: 10.1186/1471-2164-9-488 – ident: e_1_3_5_30_1 doi: 10.3945/ajcn.2008.26182 – ident: e_1_3_5_47_1 doi: 10.1210/en.2011-1600 – ident: e_1_3_5_36_1 doi: 10.1186/s13059-014-0550-8 – ident: e_1_3_5_7_1 doi: 10.1016/S0140-6736(82)90214-8 – ident: e_1_3_5_2_1 doi: 10.1016/S0090-4295(02)01847-2 – ident: e_1_3_5_22_1 doi: 10.1002/ijc.21749 – volume-title: Vitamin D (3rd Edition) year: 2011 ident: e_1_3_5_12_1 – reference: 25327758 - Prostate. 2015 Feb 15;75(3):255-65 – reference: 209750 - Arch Biochem Biophys. 1978 Jun;188(2):282-6 – reference: 1848745 - Arch Dermatol. 1991 Apr;127(4):536-8 – reference: 24789033 - Clin Cancer Res. 2014 May 1;20(9):2289-99 – reference: 24732629 - Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1494-504 – reference: 10699616 - Urology. 2000 Mar;55(3):387-90 – reference: 16140963 - Cancer Res. 2005 Sep 1;65(17):7917-25 – reference: 20543748 - Med Sci Sports Exerc. 2011 Feb;43(2):335-43 – reference: 16624828 - Carcinogenesis. 2006 Sep;27(9):1883-93 – reference: 22508710 - J Clin Endocrinol Metab. 2012 Jul;97(7):2315-24 – reference: 24897284 - Pharmacogenomics. 2014 Apr;15(6):759-74 – reference: 18245496 - Cancer Res. 2008 Feb 1;68(3):927-36 – reference: 12081833 - Am J Clin Nutr. 2002 Jul;76(1):187-92 – reference: 23975260 - Nat Protoc. 2013 Sep;8(9):1765-86 – reference: 18925949 - BMC Genomics. 2008 Oct 16;9:488 – reference: 22760568 - Am J Clin Nutr. 2012 Aug;96(2):332-6 – reference: 25085836 - Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1484-93 – reference: 11157326 - Am J Clin Nutr. 2001 Feb;73(2):288-94 – reference: 12385931 - Urology. 2002 Oct;60(4):670-4 – reference: 6119494 - Lancet. 1982 Jan 9;1(8263):74-6 – reference: 15897808 - Shock. 2005 Jun;23(6):543-8 – reference: 20736230 - Genome Res. 2010 Oct;20(10):1352-60 – reference: 22383036 - Nat Protoc. 2012 Mar 01;7(3):562-78 – reference: 19286836 - Mol Pharmacol. 2009 Jun;75(6):1392-9 – reference: 25516281 - Genome Biol. 2014;15(12):550 – reference: 19465376 - Nucleic Acids Res. 2009 Jul;37(Web Server issue):W305-11 – reference: 21537045 - J Clin Oncol. 2011 Jun 10;29(17):2378-85 – reference: 1370648 - Cancer Res. 1992 Feb 1;52(3):515-20 – reference: 24069333 - PLoS One. 2013 Sep 17;8(9):e74712 – reference: 24974387 - Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1944-7 – reference: 23220550 - J Steroid Biochem Mol Biol. 2013 Jul;136:233-7 – reference: 19064511 - Am J Clin Nutr. 2008 Dec;88(6):1519-27 – reference: 16557596 - Int J Cancer. 2006 Sep 1;119(5):1082-7 – reference: 21725204 - Epigenetics. 2011 Aug;6(8):994-1000 – reference: 20979621 - Genome Biol. 2010;11(10):R106 – reference: 16002434 - Mol Endocrinol. 2005 Nov;19(11):2685-95 – reference: 9610788 - Cancer Epidemiol Biomarkers Prev. 1998 May;7(5):391-5 – reference: 10750664 - Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):265-70 – reference: 16076349 - Semin Dial. 2005 Jul-Aug;18(4):276-89 – reference: 19290791 - Pharmacogenomics. 2009 Mar;10(3):417-33 – reference: 12520532 - J Cell Biochem. 2003 Feb 1;88(2):315-22 – reference: 22454149 - Endocrinology. 2012 Jun;153(6):2576-87 – reference: 16205698 - Br J Cancer. 2005 Oct 31;93(9):1019-23 |
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| Snippet | African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D... Aim: African–Americans (AA) have increased prostate cancer risk and a greater mortality rate than European–Americans (EA). AA exhibit a high prevalence of... |
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| SubjectTerms | African Americans African Americans - genetics African-American Aged Biomarkers Biopsy Cholecalciferol - administration & dosage Cohort Studies Dietary Supplements Disease prevention European Continental Ancestry Group - genetics Gene expression Genomes health disparities Humans Immune response Inflammation Male Middle Aged Prospective Studies prostate Prostate - drug effects Prostate - physiology Prostate - surgery Prostate cancer Prostatectomy Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - surgery Racial differences RNA-seq Student athletes Supplements Surgery Systems Analysis transcription Transcriptome - drug effects Transcriptome - genetics Vitamin D Vitamin D3 Vitamin deficiency |
| Title | Systems analysis of the prostate transcriptome in African-American men compared with European-American men |
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